Evidence map›Paper›PMID 33599608›Full record

ArticleeLife2021

Control of feeding by Piezo-mediated gut mechanosensation in

Soohong Min, Yangkyun Oh, Pushpa Verma, Samuel C Whitehead, Nilay Yapici, David Van Vactor, Greg Sb Suh, Stephen Liberles

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  5. Article
  6. Article
  7. What goes down may come up: regurgitative behaviors and their underlying gut-brain axes-insights from genetic models and related pathologies.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Review
  8. Connectomic mapping of pharyngeal and gut sensory circuits in adultbioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Gut-brain communication in Drosophila melanogaster.Current opinion in neurobiology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. The gut and heart's role in reward processing.Frontiers in integrative neuroscience · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. A gut-brain-gut interoceptive circuit loop gates sugar ingestion inbioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Soohong MinHoward Hughes Medical Institute, Harvard Medical School, Department of Cell Biology, Boston, United States.ORCID 0000-0003-0683-2935
Yangkyun OhSkirball Institute, NYU School of Medicine, New York, United States.
Pushpa VermaHarvard Medical School, Department of Cell Biology, Boston, United States.
Samuel C WhiteheadDepartment of Physics, Cornell University, Ithaca, United States.
Nilay YapiciDepartment of Neurobiology and Behavior, Cornell University, Ithaca, United States.
David Van VactorHarvard Medical School, Department of Cell Biology, Boston, United States.
Greg Sb SuhSkirball Institute, NYU School of Medicine, New York, United States.
Stephen LiberlesHoward Hughes Medical Institute, Harvard Medical School, Department of Cell Biology, Boston, United States.ORCID 0000-0002-2177-9741

Funding

Regulation of sleep by microRNAsP01NS090994 · NINDS · HARVARD MEDICAL SCHOOL · PI VAN VACTOR, DAVID L. · 2016 to 2020
$5.7M
Molecular and Neural Mechanisms Regulating Foraging and Food IntakeR35GM133698 · NIGMS · CORNELL UNIVERSITY · PI Nilay Yapici · 2019 to 2026
$2.9M
Understanding the role of the brain CRH (Corticotropin-Releasing Hormone) system in the detection and consumption of nutritional sugar.R01DK106636 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RYOO, HYUNG D · 2015 to 2019
$1.9M
Characterization of Taste-independent Sugar Sensor in the BrainR01DK116294 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RYOO, HYUNG D · 2018 to 2021
$1.7M
Howard Hughes Medical InstituteNIDDK NIH HHS R01 DK106636NIDDK NIH HHS R01 DK116294NIGMS NIH HHS R35 GM133698NIH HHS NS090994NIH HHS R35 GM133698-01NIH HHS RO1DK106636NIH HHS RO1DK116294NINDS NIH HHS P01 NS090994
6 · The paper itself

Abstract

Across animal species, meals are terminated after ingestion of large food volumes, yet underlying mechanosensory receptors have so far remained elusive. Here, we identify an essential role for

Indexed as

AnimalsDrosophila melanogasterDrosophila ProteinsFeeding BehaviorFemaleGastrointestinal TractIon ChannelsMaleMechanotransduction, CellularSensory Receptor CellsDrosophila ProteinsIon ChannelsPiezo protein, DrosophilaD. melanogasterfeedinginteroceptionmechanosensationneurosciencePiezosensory

Identifiers

PMID33599608
PMCPMC7920550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.