ArticleJournal of applied clinical medical physics2021
Investigating volumetric repainting to mitigate interplay effect on 4D robustly optimized lung cancer plans in pencil beam scanning proton therapy.
Article in Journal of applied clinical medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 28 citations in OpenAlex.
- Breathing-phase selection for gated proton therapy in lung cancer towards temporally targeted ultra-high dose rate delivery.Physics and imaging in radiation oncology · 2026Article
- Robustness of Tumor Control Against Intrafraction Patient Motion in Lung Stereotactic Body Radiation Therapy.Advances in radiation oncology · 2026Article
- Survey data analysis of treatment planning methods in particle therapy facilities.Japanese journal of radiology · 2026Article
- Geometry-based framework for beam angle selection in proton therapy for lung cancer.Physics and imaging in radiation oncology · 2026Article
- Machine Learning-Based Beam Delivery Time Model for Mevion S250i With Hyperscan Technology.International journal of particle therapy · 2026Article
- Dosimetric characteristics of cardiorespiratory motion during cardiac stereotactic body radiotherapy and dose gain from respiratory gating.Quantitative imaging in medicine and surgery · 2026Article
- Dose comparison of proton beam therapy with and without a multileaf collimator in the treatment of multiple hepatocellular carcinoma.Physics and imaging in radiation oncology · 2026Article
- An ESTRO-EPTN Delphi consensus on robustness evaluation in proton therapy.Physics and imaging in radiation oncology · 2026Article
- Commissioning and robustness evaluation of external laser sensor for respiratory gating in carbon-ion radiotherapy.Journal of applied clinical medical physics · 2026Article
- Commissioning of respiratory-gated 4D dynamic dose calculations for various gating widths without spot timestamp in proton pencil beam scanning.Medical physics · 2025Article
- Real-time gated proton therapy: Introducing clinical workflow and failure modes and effects analysis (FMEA).Technical innovations & patient support in radiation oncology · 2025Article
- The rationale for a carbon ion radiation therapy facility in Australia.Journal of medical radiation sciences · 2024Review
- Quantifying dose uncertainties resulting from cardiorespiratory motion in intensity-modulated proton therapy for cardiac stereotactic body radiotherapy.Frontiers in oncology · 2024Article
- Quality of Life and Patient-Reported Outcomes Following Proton Therapy for Oropharyngeal Carcinoma: A Systematic Review.Cancers · 2023Review
- Small spot size versus large spot size: Effect on plan quality for lung cancer in pencil beam scanning proton therapy.Journal of applied clinical medical physics · 2022Article
- Impact of errors in spot size and spot position in robustly optimized pencil beam scanning proton-based stereotactic body radiation therapy (SBRT) lung plans.Journal of applied clinical medical physics · 2021Article
- Influence of Residual Motion Within the Gating Window on Dose Distribution in Respiratory-gated Proton Therapy.In vivo (Athens, Greece)Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe interplay effect between dynamic pencil proton beams and motion of the lung tumor presents a challenge in treating lung cancer patients in pencil beam scanning (PBS) proton therapy. The main purpose of the current study was to investigate the interplay effect on the volumetric repainting lung plans with beam delivery in alternating order ("down" and "up" directions), and explore the number of volumetric repaintings needed to achieve acceptable lung cancer PBS proton plan.
methodThe current retrospective study included ten lung cancer patients. The total dose prescription to the clinical target volume (CTV) was 70 Gy(RBE) with a fractional dose of 2 Gy(RBE). All treatment plans were robustly optimized on all ten phases in the 4DCT data set. The Monte Carlo algorithm was used for the 4D robust optimization, as well as for the final dose calculation. The interplay effect was evaluated for both the nominal (i.e., without repainting) as well as volumetric repainting plans. The interplay evaluation was carried out for each of the ten different phases as the starting phases. Several dosimetric metrics were included to evaluate the worst-case scenario (WCS) and bandwidth based on the results obtained from treatment delivery starting in ten different breathing phases.
resultsThe number of repaintings needed to meet the criteria 1 (CR1) of target coverage (D
conclusionThe number of repaintings required to mitigate the interplay effect in PBS lung cancer (tumor motion < 15 mm) was found to be highly patient dependent. For the volumetric repainting with an alternating order, a patient-specific interplay evaluation strategy must be adopted. Determining the optimal number of repaintings based on the bandwidth and WCS approach could mitigate the interplay effect in PBS lung cancer treatment.
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