Evidence map›Paper›PMID 33599094›Full record

ArticleMolecular nutrition & food research2021

Gut Microbial and Metabolic Profiling Reveal the Lingering Effects of Infantile Iron Deficiency Unless Treated with Iron.

Jordi Mayneris-Perxachs, Wellington Amaral, Gabriele R Lubach, Mark Lyte, Gregory J Phillips, Joram M Posma, Christopher L Coe, Jonathan R Swann

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Jordi Mayneris-PerxachsDepartment of Diabetes, Endocrinology and Nutrition, Josep Trueta University Hospital, Girona, Spain.ORCID 0000-0003-3788-3815
Wellington AmaralHarlow Center for Biological Psychology, University of Wisconsin, Madison, WI, USA.
Gabriele R LubachHarlow Center for Biological Psychology, University of Wisconsin, Madison, WI, USA.
Mark LyteCollege of Veterinary Medicine, Iowa State University.
Gregory J PhillipsCollege of Veterinary Medicine, Iowa State University.
Joram M PosmaDepartment of Metabolism, DigCIBER in Physiopathology of estion and Reproduction, Imperial College London, UK.
Christopher L CoeHarlow Center for Biological Psychology, University of Wisconsin, Madison, WI, USA.
Jonathan R SwannDepartment of Metabolism, DigCIBER in Physiopathology of estion and Reproduction, Imperial College London, UK.ORCID 0000-0002-6485-4529
University of Wisconsin–Madison · USIowa State University · USImperial College London · GBKarolinska Institutet · SESpanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition · ES

Funding

Interdisciplinary Training for Autism Researchers(RMI)T32MH073124 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI Stephen Charles Noctor, Christine Wu Nordahl · 2004 to 2026
$6.8M
Detection and Correction of Iron Deficiency Induced Abnormal Brain MetabolismR01HD089989 · NICHD · UNIVERSITY OF MINNESOTA · PI COE, CHRISTOPHER L, GEORGIEFF, MICHAEL K. · 2017 to 2021
$2.7M
Maternal and Infant Microbiome Determinants of Brain and Behavioral DevelopmentR33MH104198 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI COE, CHRISTOPHER L, LYTE, MARK · 2016 to 2018
$2.3M
Novel Medical Food for Treating Infant Anemia and Iron Deficiency in the CNSR01HD080201 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI COE, CHRISTOPHER L · 2014 to 2018
$2.1M
Medical Research Council MR/S004033/1NICHD NIH HHS R01 HD080201NICHD NIH HHS R01 HD089989NIMH NIH HHS R33 MH104198NIMH NIH HHS T32 MH073124
6 · The paper itself

Abstract

scopeIron deficiency (ID) compromises the health of infants worldwide. Although readily treated with iron, concerns remain about the persistence of some effects. Metabolic and gut microbial consequences of infantile ID were investigated in juvenile monkeys after natural recovery (pID) from iron deficiency or post-treatment with iron dextran and B vitamins (pID+Fe). METHODS AND

resultsMetabolomic profiling of urine and plasma is conducted with

conclusionsLingering metabolic and microbial effects are found after natural recovery from ID. These long-term biochemical derangements are not present in the pID+Fe animals emphasizing the importance of the early detection and treatment of early-life ID to ameliorate its chronic metabolic effects.

Indexed as

Anemia, Iron-DeficiencyAnimalsAnimals, NewbornBlood Chemical AnalysisDisease Models, AnimalFemaleGastrointestinal MicrobiomeIron-Dextran ComplexMacaca mulattaMetabolomeRNA, Ribosomal, 16SUrineIron-Dextran ComplexRNA, Ribosomal, 16Sanemiairon deficiencyiron supplementationmetabolismmetabolomemicrobiomemicrobiotamonkey

Identifiers

PMID33599094
PMCPMC8216173
OpenAlexW3129943882

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.