Evidence map›Paper›PMID 33598866›Full record

ArticleAIDS and behavior2021

Depression and Viral Suppression Among Adults Living with HIV in Tanzania.

Mathilda Regan, Alfa Muhihi, Tumaini Nagu, Said Aboud, Nzovu Ulenga, Sylvia Kaaya, Mary C Smith Fawzi, Aisha K Yousafzai, Ferdinand Mugusi, Wafaie W Fawzi and 3 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in AIDS and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07080138 (Research on the Psychological Status of Patients With HIV-1 Infection), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07080138 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Research on the Psychological Status of Patients With HIV-1 Infection

TypeobservationalSponsorShanxi Bethune HospitalRan2025 to 2026Enrolled500ConditionsHIV-1-infection, Anxiety DepressionArmsAll kinds of INSTI medications, All kinds of conventional medications
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Mathilda ReganDepartment of Global Health and Population, Harvard T H Chan School of Public Health, 655 Huntington Ave, Boston, MA, 02115, USA. mregan@g.harvard.edu.ORCID http://orcid.org/0000-0001-6376-3935
Alfa MuhihiManagement and Development for Health, Dar es Salaam, Tanzania.
Tumaini NaguManagement and Development for Health, Dar es Salaam, Tanzania.
Said AboudManagement and Development for Health, Dar es Salaam, Tanzania.
Nzovu UlengaManagement and Development for Health, Dar es Salaam, Tanzania.
Sylvia KaayaDepartment of Psychiatry and Mental Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Mary C Smith FawziDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA.
Aisha K YousafzaiDepartment of Global Health and Population, Harvard T H Chan School of Public Health, 655 Huntington Ave, Boston, MA, 02115, USA.
Ferdinand MugusiDepartment of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Wafaie W FawziDepartment of Global Health and Population, Harvard T H Chan School of Public Health, 655 Huntington Ave, Boston, MA, 02115, USA.
Shekhar SaxenaDepartment of Global Health and Population, Harvard T H Chan School of Public Health, 655 Huntington Ave, Boston, MA, 02115, USA.
Karestan KoenenDepartment of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA, USA.
Christopher R SudfeldDepartment of Global Health and Population, Harvard T H Chan School of Public Health, 655 Huntington Ave, Boston, MA, 02115, USA.
Harvard Global Health Institute · USMuhimbili University of Health and Allied Sciences · TZHarvard University · USManagement and Development for Health · TZ

Funding

BIOSTATISTICS/EPIDEMIOLOGY TRAINING GRANTS IN AIDST32AI007358 · NIAID · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Michael David Hughes · 1989 to 2026
$12.4M
Trial of Vitamin D in HIV ProgressionR01DK098075 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI FAWZI, WAFAIE W · 2013 to 2017
$2.6M
NIAID NIH HHS T32 AI007358NIDDK NIH HHS R01 DK098075NIDDK NIH HHS R01DK098075NIH HHS 5T32AI007358 - 32
6 · The paper itself

Abstract

Limited information is available on the association between depression and viral suppression among people living with HIV (PLH) in sub-Saharan Africa. We conducted a prospective cohort study of 3996 adults initiating antiretroviral therapy (ART) in Dar es Salaam, Tanzania. Log-binomial models were used to assess the association between depression and the risk of an unsuppressed viral load (> 400 copies/mL) after 6 months of ART. Women who had depression at both initiation and after 6 months of treatment had 1.94 times (95% CI 1.22, 3.09; z = 2.78, p < 0.01) the risk of an unsuppressed viral load after 6 months of treatment as compared to women who did not have depression at either time point. Men with the top tertile of depressive symptoms after 6 months of treatment had 1.58 times the risk of an unsuppressed viral load (95% CI 1.04, 2.38; z = 2.15, p = 0.03) as compared to the lowest tertile. Research should be pursued on interventions to prevent and address depression among adults initiating ART to potentially support achievement of viral suppression.

Indexed as

DepressionHIV InfectionsAdultFemaleHumansMaleProspective StudiesTanzaniaViral LoadDepressionGenderSub-Saharan AfricaTanzaniaViral suppression

Identifiers

PMID33598866
PMCPMC8368084
OpenAlexW3129726529

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.