ArticleChromosoma1988
Structural analysis of the mitotic cycle in pre-gastrula Xenopus embryos.
Article in Chromosoma, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Chromosomes remain individualized through interphase in embryos of the tardigradebioRxiv : the preprint server for biology · 2025Article
- A nuclear house divided.Science (New York, N.Y.) · 2025Article
- Genome wide decrease of DNA replication eye density at the midblastula transition ofCell cycle (Georgetown, Tex.) · 2019Article
- A NuRD Complex from Xenopus laevis Eggs Is Essential for DNA Replication during Early Embryogenesis.Cell reports · 2018Article
- Biological Scaling Problems and Solutions in Amphibians.Cold Spring Harbor perspectives in biology · 2015Review
- Morphology and function of membrane-bound organelles.Current opinion in cell biology · 2014Review
- Dynamic assembly of brambleberry mediates nuclear envelope fusion during early development.Cell · 2012Article
- Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage.Nature communications · 2012Article
- The midblastula transition defines the onset of Y RNA-dependent DNA replication in Xenopus laevis.Molecular and cellular biology · 2011Article
- Fission yeast cells undergo nuclear division in the absence of spindle microtubules.PLoS biology · 2010Article
- Sizing up the nucleus: nuclear shape, size and nuclear-envelope assembly.Journal of cell science · 2009Review
- Dynamics of the genome during early Xenopus laevis development: karyomeres as independent units of replication.The Journal of cell biology · 1998Article
- Site-specific initiation of DNA replication in Xenopus egg extract requires nuclear structure.Molecular and cellular biology · 1995Article
- Local and global changes in the morphology and distribution of replication centres in rapidly expanding nuclei.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1995Article
- Chromosomal replication initiates and terminates at random sequences but at regular intervals in the ribosomal DNA of Xenopus early embryos.The EMBO journal · 1993Article
- Differential compartmentalization of plasmid DNA microinjected into Xenopus laevis embryos relates to replication efficiency.Molecular and cellular biology · 1991Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The long-known phenomenon of karyomere (chromosome vesicle) formation at early telophase of the nuclear cycle during early embryogenesis of a wide range of organisms including amphibians (Rubaschkin 1905; for review, see Richards 1917) was investigated in the early cleavage cycles of Xenopus laevis embryos before the mid blastula transition. Embryos were fixed and Epon embedded at successive time intervals and consecutive thick (3 micron) and ultrathin sections cut. Using conventional light microscopy at low magnification as well as phase and/or interference contrast video microscopy at high magnification, a substantial amount of information could be obtained from the analysis of optical sections in thick-sectioned material. In addition, details of the ultrastructural organization could be analysed from corresponding ultrathin sections by electron microscopy. The light microscopic analysis of serial thick sections allowed precise determination of the arrangement and sizes of telophase karyomere structures during the embryonic nuclear division cycle. It was found that small, widely spaced 1st order karyomeres fuse to larger (2nd order) karyomeres which then progressively exhibit lateral fusion of neighbouring karyomeres. The final coalescence of adjacent karyomeres marks the onset of the reorganization of the typical interphase nuclear structure. The data are discussed with regard to the occurrence of karyomeres during the embryonic nuclear cycle of arthropods, dipteran insects, and echinoderms as well as recent progress in the use of Xenopus egg extracts for in vitro assembly of nuclear structures around protein-free DNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.