ArticleJournal of neurology2021
Long term follow-up in advanced Parkinson's disease treated with DBS of the subthalamic nucleus.
Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Deep brain stimulation for dystonia treatment in cerebral palsy: efficacy exploration.Experimental biology and medicine (Maywood, N.J.) · 2025Pooled it
- Economic Evaluations Comparing Deep Brain Stimulation to Best Medical Therapy for Movement Disorders: A Meta-Analysis.PharmacoEconomics · 2024Pooled it
- Deep Brain Stimulation in Parkinson Disease: A Meta-analysis of the Long-term Neuropsychological Outcomes.Neuropsychology review · 2023Pooled it
- Pooled it
- Cognitive Impact of Deep Brain Stimulation in Parkinson's Disease Patients: A Systematic Review.Frontiers in human neuroscience · 2022Pooled it
- Prospective Long-term Follow-up of Focused Ultrasound Unilateral Subthalamotomy for Parkinson Disease.Neurology · 2023Trial
- Iranian Deep Brain Stimulation Registry for Parkinson's Disease (IDBSR-PD): establishment and feasibility study.Acta neurologica Belgica · 2026Article
- Long term improvement in quality of life in Parkinson's disease after deep brain stimulation of the subthalamic nucleus: an observational cohort.Clinical parkinsonism & related disorders · 2026Article
- Cognitive effects of adaptive deep brain stimulation in Parkinson's disease: stability without risk.European journal of medical research · 2025Article
- Long-term efficacy of deep brain stimulation in Parkinson's disease: over 10-year follow-up and insights into the "DBS honeymoon".Therapeutic advances in neurological disorders · 2025Article
- Significance of neurodegeneration and neuroplasticity serum biomarkers in Parkinson's disease patients treated with subthalamic stimulation.NPJ Parkinson's disease · 2024Article
- Effects of STN-DBS surgery on cerebral glucose metabolism and distribution of DAT in Parkinson's disease.Brain and behavior · 2023Article
- Long-term follow-up of Parkinsonian patients operated on with deep brain electromodulation without intraoperative microrecording.Surgical neurology international · 2023Article
- Axial impairment and falls in Parkinson's disease: 15 years of subthalamic deep brain stimulation.NPJ Parkinson's disease · 2022Article
- How Does Deep Brain Stimulation Change the Course of Parkinson's Disease?Movement disorders : official journal of the Movement Disorder Society · 2022Review
- Induced Cognitive Impairments Reversed by Grafts of Neural Precursors: A Longitudinal Study in a Macaque Model of Parkinson's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson's disease (PD) is the second most common neurodegenerative disorder, affecting both motor and non-motor systems. Deep brain stimulation of the subthalamic nucleus (STN-DBS) has been an approved treatment for PD for more than 30 years, but few data are available regarding its long-term effectiveness.
objectiveThe aim of this study is to evaluate patients' outcome, both from a motor and non-motor perspective, 9 to 14 years after DBS implantation. We have investigated patients with advanced PD and treated with STN-DBS, in relation to key clinical features of PD.
methods18 patients were assessed both retrospectively and prospectively. They underwent motor examination, neuropsychological evaluation and questionnaires on the quality of life, preoperatively, as well as 1, 9 and 14 years after DBS surgery. All patients were implanted with STN-DBS at San Raffaele Hospital between 2004 and 2010.
results13 males and five females underwent DBS implantation with a mean PD duration of 11 years. Stimulation significantly improved med-off/stim-on condition up to 9 years, compared to the preoperative off state, and med-on/stim-on condition at 14 years, compared to med-on/stim-off state. Long term improvement specifically involved tremor and rigidity, as well as dopaminergic daily dose. At the same time, STN-DBS had no long-lasting effect on axial symptoms and cognitive functions.
conclusionsSTN-DBS remains an effective therapy for advanced PD, also over the years. Despite the underlying progression of the disease, this treatment extends the period in which the overall quality of life is still acceptable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.