Evidence map›Paper›PMID 33598759›Full record

Trial reportBrain structure & function2021

Methylphenidate decreases the EEG mu power in the right primary motor cortex in healthy adults during motor imagery and execution.

Danielle Aprigio, Juliana Bittencourt, Mariana Gongora, Victor Marinho, Silmar Teixeira, Victor Hugo Bastos, Mauricio Cagy, Henning Budde, Pedro Ribeiro, Luis Fernando Basile and 1 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Brain structure & function, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Danielle AprigioBrain Mapping and Sensory Motor Integration Laboratory, Institute of Psychiatry of Federal, University of Rio de Janeiro, Rio de Janeiro, Brazil.
Juliana BittencourtNeurophysiology and Neuropsychology of Attention Laboratory, Institute of Psychiatry of the Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Mariana GongoraBrain Mapping and Sensory Motor Integration Laboratory, Institute of Psychiatry of Federal, University of Rio de Janeiro, Rio de Janeiro, Brazil.
Victor MarinhoThe Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, Brazil. victormarinhophb@hotmail.com.ORCID http://orcid.org/0000-0003-4800-7298
Silmar TeixeiraThe Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, Brazil.
Victor Hugo BastosThe Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, Brazil.
Mauricio CagyBrain Mapping and Sensory Motor Integration Laboratory, Institute of Psychiatry of Federal, University of Rio de Janeiro, Rio de Janeiro, Brazil.
Henning BuddeFaculty of Human Sciences, Medical School Hamburg, Sport Science, Reykjavik University, Reykjavik, Iceland.
Pedro RibeiroBrain Mapping and Sensory Motor Integration Laboratory, Institute of Psychiatry of Federal, University of Rio de Janeiro, Rio de Janeiro, Brazil.
Luis Fernando BasileDivision of Neurosurgery, University of São Paulo Medical School, São Paulo, Brazil.
Bruna VelasquesNeurophysiology and Neuropsychology of Attention Laboratory, Institute of Psychiatry of the Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro · BRUniversidade Federal do Piauí · BRReykjavík University · ISUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the effects of dopaminergic drugs on the EEG mu power during motor imagery, action observation, and execution. This is a double-blind, crossover study with a sample of 15 healthy adults under placebo vs. methylphenidate vs. risperidone conditions during motor imagery, action observation, and execution tasks. The participants had drug dosage adjustment based on body weight/dose (mg/kg). We also analyzed the mu band power by electroencephalography during the study steps. The main result is the interaction between the condition and task factors for the C3 and C4 electrodes, with decreasing EEG mu power in the methylphenidate when compared to risperidone (p ≤ 0.0083). Our results can indicate that the methylphenidate decreases the neurophysiological activity in the central cortical regions during the perceptual experience of tasks with or without body movement.

Indexed as

Motor CortexAdultCross-Over StudiesElectroencephalographyHumansImaginationMethylphenidateMovementRisperidoneMethylphenidateRisperidoneElectroencephalographyMethylphenidateMotor imageryMu band powerRisperidone

Identifiers

PMID33598759
OpenAlexW3132514615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.