ArticleEJNMMI physics2021
Theranostic SPECT reconstruction for improved resolution: application to radionuclide therapy dosimetry.
Article in EJNMMI physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
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- Super-Resolution Reconstruction and Detector Geometric Error Correction for Parallel-Beam Low-Resolution Multi-Detector SPECT: A Proof of Concept.Tomography (Ann Arbor, Mich.) · 2026Article
- MIRD Pamphlet No. 33: MIRDpvc-A Software Tool for Recovery Coefficient-Based Partial-Volume Correction.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- A Narrative Review of Theranostics in Neuro-Oncology: Advancing Brain Tumor Diagnosis and Treatment Through Nuclear Medicine and Artificial Intelligence.International journal of molecular sciences · 2025Review
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- A review of state-of-the-art resolution improvement techniques in SPECT imaging.EJNMMI physics · 2025Review
- NEMA NU 1-2018 performance characterization and Monte Carlo model validation of the Cubresa Spark SiPM-based preclinical SPECT scanner.EJNMMI physics · 2023Article
- Triple modality image reconstruction of PET data using SPECT, PET, CT information increases lesion uptake in images of patients treated with radioembolization withEJNMMI physics · 2023Article
- Investigation and optimization of PET-guided SPECT reconstructions for improved radionuclide therapy dosimetry estimates.Frontiers in nuclear medicine · 2023Article
- Partial volume effect in SPECT & PET imaging and impact on radionuclide dosimetry estimates.Asia Oceania journal of nuclear medicine & biology · 2023Article
- Towards accurate partial volume correction inEJNMMI physics · 2022Article
- Multimodality imaging of nanoparticle-based vaccines: Shedding light on immunology.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022Review
- Hybrid kernelised expectation maximisation for Bremsstrahlung SPECT reconstruction in SIRT withEJNMMI physics · 2022Article
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Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundSPECT-derived dose estimates in tissues of diameter less than 3× system resolution are subject to significant losses due to the limited spatial resolution of the gamma camera. Incorporating resolution modelling (RM) into the SPECT reconstruction has been proposed as a possible solution; however, the images produced are prone to noise amplification and Gibbs artefacts. We propose a novel approach to SPECT reconstruction in a theranostic setting, which we term SPECTRE (single photon emission computed theranostic reconstruction); using a diagnostic PET image, with its superior resolution, to guide the SPECT reconstruction of the therapeutic equivalent. This report demonstrates a proof in principle of this approach.
methodsWe have employed the hybrid kernelised expectation maximisation (HKEM) algorithm implemented in STIR, with the aim of producing SPECT images with PET-equivalent resolution. We demonstrate its application in both a dual
resultsSPECTRE is shown to produce images comparable in accuracy and recovery to PET with minimal introduction of artefacts and amplification of noise.
conclusionThe SPECTRE approach to image reconstruction shows improved quantitative accuracy with a reduction in noise amplification. SPECTRE shows great promise as a method of improving SPECT radioactivity concentrations, directly leading to more accurate dosimetry estimates in small structures and target lesions. Further investigation and optimisation of the algorithm parameters is needed before this reconstruction method can be utilised in a clinical setting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.