Evidence map›Paper›PMID 33598559›Full record

ArticleEuropean stroke journal2020

Non-invasive brain stimulation as add-on therapy for subacute post-stroke aphasia: a randomized trial (NORTHSTAR).

Anna Zumbansen, Sandra E Black, Joyce L Chen, Dylan J Edwards, Alexander Hartmann, Wolf-Dieter Heiss, Sylvain Lanthier, Paul Lesperance, George Mochizuki, Caroline Paquette and 7 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European stroke journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02020421 (NOn-invasive Repeated THerapeutic STimulation for Aphasia Recovery), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02020421 nacompletednot on this map

NOn-invasive Repeated THerapeutic STimulation for Aphasia Recovery

TypeinterventionalSponsorDr. Alexander ThielRan2013 to 2018Enrolled63ConditionsAphasiaArmsrTMS, tDCS, Sham rTMS, Sham tDCS
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  14. Reversing the Ruin: Rehabilitation, Recovery, and Restoration After Stroke.Current neurology and neuroscience reports · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 4 countries.

Anna ZumbansenJewish General Hospital, Lady Davis Institute for Medical Research, Department of Neurology & Neurosurgery, McGill University, Montreal, Quebec.ORCID https://orcid.org/0000-0003-2332-8263
Sandra E BlackDepartment of Medicine-Neurology and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario.
Joyce L ChenFaculty of Kinesiology and Physical Education, and Rehabilitation Sciences Institute, University of Toronto, Toronto, Ontario.
Dylan J EdwardsBurke Neurological Institute, White Plains, NY, USA.
Alexander HartmannDepartment of Neurosurgery, Hospital of the City of Cologne, University of Witten-Herdecke, Germany.
Wolf-Dieter HeissMax Planck Institute für Stoffwechsel Forschung -- MPI for Metabolism Research, and Department of Neurology, Universität zu Köln, Cologne, Germany.
Sylvain LanthierHôpital du Sacré-Cœur de Montreal, and Department of medicine, Université de Montréal, Quebec.ORCID https://orcid.org/0000-0001-9762-5514
Paul LesperanceCHUM, Université de Montréal, Montreal, Quebec.
George MochizukiSchool of Kinesiology and Health Science, York University, Toronto, Ontario.
Caroline PaquetteDepartment of Kinesiology and Physical Education, McGill University, Montreal, Quebec.
Elizabeth A RochonToronto Rehabilitation Institute, and Department of Speech-Language Pathology, University of Toronto, Toronto, Ontario.
Ilona Rubi-FessenRehaNova Neurologische Rehabilitationsklinik, Cologne, Germany.
Jennie VallesBurke Rehabilitation Hospital, White Plains, NY, USA.
Heike KneifelRehaNova Neurologische Rehabilitationsklinik, Cologne, Germany.
Susan Wortman-JuttBurke Neurological Institute, White Plains, NY, USA.
Alexander ThielJewish General Hospital, Lady Davis Institute for Medical Research, Department of Neurology & Neurosurgery, McGill University, Montreal, Quebec.
NORTHSTAR-study group
Burke Rehabilitation Hospital · USJewish General Hospital · CAKlinik und Poliklinik für Neurologie · DEUniversity of Toronto · CACentre Hospitalier de l’Université de Montréal · CAEdith Cowan University · AUHôpital du Sacré-Cœur de Montréal · CAMcGill University · CASunnybrook Health Science Centre · CAUniversity of Cologne · DEWitten/Herdecke University · DEYork University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNon-invasive brain stimulation (NIBS) with speech therapy might improve recovery from post-stroke aphasia. This three-armed sham-controlled blinded prospective proof-of-concept study tested 1 Hz subthreshold repetitive transcranial magnetic stimulation (rTMS) and 2-mA cathodal transcranial direct current stimulation (ctDCS) on the right pars triangularis in subacute post-stroke aphasia. PATIENTS AND

methodsSixty-three patients with left middle cerebral artery infarcts were recruited in five hospitals (Canada/United States/Germany, 01-2014/03-2018) and randomized to receive rTMS (

resultsNaming was significantly improved by rTMS (median = 1.91/interquartile range = 0.77/

Indexed as

Aphasialanguage therapyrandomized control trialspeech therapystroketranscranial direct current stimulationtranscranial magnetic stimulation

Identifiers

PMID33598559
PMCPMC7856587
OpenAlexW3040647154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.