Evidence map›Paper›PMID 33598464›Full record

ArticleFrontiers in cell and developmental biology2021

Induced Arp2/3 Complex Depletion Increases FMNL2/3 Formin Expression and Filopodia Formation.

Vanessa Dimchev, Ines Lahmann, Stefan A Koestler, Frieda Kage, Georgi Dimchev, Anika Steffen, Theresia E B Stradal, Franz Vauti, Hans-Henning Arnold, Klemens Rottner

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 49 citations in OpenAlex.

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  11. The Arp2/3 complex is required forbioRxiv : the preprint server for biology · 2025
    Article
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  18. Chiral growth of adherent filopodia.Biophysical journal · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Vanessa DimchevZoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.
Ines LahmannZoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.
Stefan A KoestlerDepartment of Cell Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Frieda KageZoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.
Georgi DimchevZoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.
Anika SteffenDepartment of Cell Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Theresia E B StradalDepartment of Cell Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Franz VautiZoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.
Hans-Henning ArnoldZoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.
Klemens RottnerZoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.
Helmholtz Centre for Infection Research · DETechnische Universität Braunschweig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Arp2/3 complex generates branched actin filament networks operating in cell edge protrusion and vesicle trafficking. Here we employ a conditional knockout mouse model permitting tissue- or cell-type specific deletion of the murine

Indexed as

cell divisionchemotaxisF-actin branchingF-actin turnoverfilopodiumlamellipodiummigrationnuclear envelope breakdown

Identifiers

PMID33598464
PMCPMC7882613
OpenAlexW3126782492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.