Evidence map›Paper›PMID 33598097›Full record

ArticleComputational and structural biotechnology journal2021

Identification of potential descriptors of water-soluble fullerene derivatives responsible for antitumor effects on lung cancer cells via QSAR analysis.

Hung-Jin Huang, Margarita Chetyrkina, Chui-Wei Wong, Olga A Kraevaya, Alexander V Zhilenkov, Ilya I Voronov, Pei-Hwa Wang, Pavel A Troshin, Shan-Hui Hsu

Abstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Thiophene-based water-soluble CBiomaterials translational · 2025
    Article
  4. Article
  5. Fullerene CInternational journal of molecular sciences · 2024
    Article
  6. Article
  7. Article
  8. Water-Soluble Fullerene CMicroorganisms · 2023
    Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hung-Jin HuangInstitute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, ROC.
Margarita ChetyrkinaSkolkovo Institute of Science and Technology, Moscow, Russian Federation.
Chui-Wei WongInstitute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, ROC.
Olga A KraevayaSkolkovo Institute of Science and Technology, Moscow, Russian Federation.
Alexander V ZhilenkovInstitute for Problems of Chemical Physics of Russian Academy of Sciences, Chernogolovka, Russian Federation.
Ilya I VoronovInstitute for Problems of Chemical Physics of Russian Academy of Sciences, Chernogolovka, Russian Federation.
Pei-Hwa WangDepartment of Animal Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.
Pavel A TroshinInstitute for Problems of Chemical Physics of Russian Academy of Sciences, Chernogolovka, Russian Federation.
Shan-Hui HsuInstitute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, ROC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Water-soluble fullerene derivatives are actively investigated as potential drugs for cancer treatment due to their favorable membranotropic properties. Herein, cytotoxic effects of twenty fullerene derivatives with different solubilizing addends were evaluated in three different types of non-small-cell lung carcinoma (NSCLC). The potential structural descriptors of the solubilizing addends related to the inhibitory activities on each type of lung cancer cell were investigated by the quantitative structure-activity relationship (QSAR) approach. The determination coefficient

Indexed as

AntitumorGenetic algorithmNSCLCQSARWater-soluble fullerene derivatives

Identifiers

PMID33598097
PMCPMC7847972

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.