Evidence map›Paper›PMID 33597916›Full record

ReviewFrontiers in neurology2021

Naturalistic Intensities of Light at Night: A Review of the Potent Effects of Very Dim Light on Circadian Responses and Considerations for Translational Research.

Thijs J Walbeek, Elizabeth M Harrison, Michael R Gorman, Gena L Glickman

Abstract readReview
In one paragraph

Review in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Thijs J WalbeekCenter for Circadian Biology, University of California, San Diego, La Jolla, CA, United States.
Elizabeth M HarrisonCenter for Circadian Biology, University of California, San Diego, La Jolla, CA, United States.
Michael R GormanCenter for Circadian Biology, University of California, San Diego, La Jolla, CA, United States.
Gena L GlickmanCenter for Circadian Biology, University of California, San Diego, La Jolla, CA, United States.

Funding

Androgen receptors and sex differences in the biological clockR01NS102962 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI BUTLER, MATTHEW P · 2018 to 2022
$2.3M
NINDS NIH HHS R01 NS102962
6 · The paper itself

Abstract

In this review, we discuss the remarkable potency and potential applications of a form of light that is often overlooked in a circadian context: naturalistic levels of dim light at night (nLAN), equivalent to intensities produced by the moon and stars. It is often assumed that such low levels of light do not produce circadian responses typically associated with brighter light levels. A solid understanding of the impacts of very low light levels is complicated further by the broad use of the somewhat ambiguous term "dim light," which has been used to describe light levels ranging seven orders of magnitude. Here, we lay out the argument that nLAN exerts potent circadian effects on numerous mammalian species, and that given conservation of anatomy and function, the efficacy of light in this range in humans warrants further investigation. We also provide recommendations for the field of chronobiological research, including minimum requirements for the measurement and reporting of light, standardization of terminology (specifically as it pertains to "dim" light), and ideas for reconsidering old data and designing new studies.

Indexed as

circadiandim lightentrainmentnLANparametric effectsphysiologytranslation

Identifiers

PMID33597916
PMCPMC7882611

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.