Evidence map›Paper›PMID 33597885›Full record

ArticleFrontiers in pharmacology2020

Carveol a Naturally-Derived Potent and Emerging Nrf2 Activator Protects Against Acetaminophen-Induced Hepatotoxicity.

Zaif Ur Rahman, Lina Tariq Al Kury, Abdullah Alattar, Zhen Tan, Reem Alshaman, Imran Malik, Haroon Badshah, Zia Uddin, Atif Ali Khan Khalil, Naveed Muhammad and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 4 countries.

Zaif Ur RahmanShenzhen University Clinical Research Center for Neurological Diseases, Health Management Center, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen, China.
Lina Tariq Al KuryCollege of Natural and Health Sciences, Zayed University, Abu Dhabi, United Arab Emirates.
Abdullah AlattarDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Zhen TanShenzhen University Clinical Research Center for Neurological Diseases, Health Management Center, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen, China.
Reem AlshamanDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Imran MalikRiphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.
Haroon BadshahDepartment of Pharmacy, Abdul Wali Khan University, Khyber Pakhtunkhwa, Pakistan.
Zia UddinDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan.
Atif Ali Khan KhalilDepartment of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan.
Naveed MuhammadDepartment of Pharmacy, Abdul Wali Khan University, Khyber Pakhtunkhwa, Pakistan.
Saifullah KhanDepartment of Microbiology and Biotechnology, Abasyn University Peshawar, Khyber Pakhtunkhwa, Pakistan.
Amjad AliDepartment of Botany, University of Malakand, Khyber Pakhtunkhwa, Pakistan.
Fawad Ali ShahRiphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.
Jing Bo LiShenzhen University Clinical Research Center for Neurological Diseases, Health Management Center, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen, China.
Shupeng LiState Key Laboratory of Oncogenomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, China.
Shenzhen University · CNAbdul Wali Khan University Mardan · PKRiphah International University · PKUniversity of Tabuk · SAAbasyn University · PKCOMSATS University Islamabad · PKNational University of Medical Sciences · PKPeking University · CNUniversity of Malakand · PKZayed University · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetaminophen (N-acetyl p-aminophenol or APAP) is used worldwide for its antipyretic and anti-inflammatory potential. However, APAP overdose sometimes causes severe liver damage. In this study, we elucidated the protective effects of carveol in liver injury, using molecular and

Indexed as

acetaminophenanti-inflammatorycarveolhepatotoxicityNrf2 pathway

Identifiers

PMID33597885
PMCPMC7883019
OpenAlexW3123627312

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.