ArticleSarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG2020
Pulmonary Low Attenuation Areas on CT in ANCA-associated Vasculitis: A quantitative and semi-quantitative analysis correlated with pulmonary function testing for obstructive airway disease.
Article in Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 3 citations in OpenAlex.
- Pulmonary and Renal Predictors of Mortality in ANCA-Associated Vasculitis: A Regional Experience from Türkiye.Biomedicines · 2025Article
- Insights into the paradoxical effect of smoking on vasculitis: a comprehensive review.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2024Article
- Quantitative CT in mortality prediction in pulmonary fibrosis with or without emphysema.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2021Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveA subset of ANCA-associated vasculitis (AAV) patients are known to manifest obstructive airway disease. Using low attenuation areas (LAA) in the lung on HRCT as an imaging marker for obstructive airway disease, we analyze HRCT studies in AAV patients compared to a matched non-AAV group using visual semi-quantitative and automated quantitative analysis for presence and severity of LAA. Furthermore, HRCT and pulmonary function testing are compared to assess agreement between tests for airway obstruction. MATERIALS AND
methods100 randomly selected AAV patients with HRCT were compared to 100 best-fit matched control subjects. HRCT cases were visually assessed for LAA, along with additional pulmonary patterns. Automated quantitative software analyzed images for texture features and volume of attenuation values of -950 HU or less (e-950). Evidence of obstructive airway disease established by pulmonary function testing, when available, was compared to HRCT analysis for LAA. Additional clinical information, diagnostic testing and mortality data were also compared.
resultsBoth study groups were comprised of 57 females and 43 males with 35 smokers averaging 10.7 pk/yrs, with average age for the AAV and control groups being 59.4 yrs and 61.9 yrs, respectively. Visually, 46 AAV patients demonstrated LAA on HRCT compared to 25 control patients (p=0.0017) with the difference in LAA presence entirely within the non-smoking subgroup (25 to 3, respectively, p=<0.0001). Quantitatively, greater than 5% e-950 demonstrated similar significant differences between AAV (36/100) and controls (19/100) (p=0.0065), predominantly in non-smokers (p=0.006). Obstruction on PFTs was significantly increased in AAV (p=0.002) with moderate agreement of obstructive disease with visual LAA on CT (Kappa 0.509). Of the obstructive disease metrics, visual LAA on CT correlated best with mortality (p=0.0085).
conclusionVisual LAA and automated quantitative analysis for e-950 on HRCT demonstrate statistically significant increases in AAV patients compared to age, gender and smoking matched controls, with differences primarily seen in the non-smoking subset. AAV revealed statistically significant greater obstructive pulmonary disease on PFTs
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