Evidence map›Paper›PMID 33597752›Full record

ArticleNature2021

Glutamate transporters have a chloride channel with two hydrophobic gates.

Ichia Chen, Shashank Pant, Qianyi Wu, Rosemary J Cater, Meghna Sobti, Robert J Vandenberg, Alastair G Stewart, Emad Tajkhorshid, Josep Font, Renae M Ryan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 64 citations in OpenAlex.

  1. A short history of Auto-Rickshaw.Acta crystallographica. Section D, Structural biology · 2026
    Review
  2. Review
  3. Overactive EAAT1 ClActa neuropathologica communications · 2026
    Article
  4. Article
  5. Article
  6. Multimodal dynamics control activity of a glial glutamate transporter.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Conformational free energy landscape of a glutamate transporter and microscopic details of its transport mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ichia Chen *Transporter Biology Group, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Shashank Pant *NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0002-8222-3616
Qianyi Wu *Transporter Biology Group, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-4991-1692
Rosemary J CaterTransporter Biology Group, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Meghna SobtiMolecular, Structural and Computational Biology Division, The Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Robert J VandenbergTransporter Biology Group, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Alastair G StewartMolecular, Structural and Computational Biology Division, The Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.ORCID http://orcid.org/0000-0002-2070-6030
Emad TajkhorshidNIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. emad@illinois.edu.ORCID http://orcid.org/0000-0001-8434-1010
Josep FontTransporter Biology Group, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia. josep.font@sydney.edu.au.ORCID http://orcid.org/0000-0001-5284-1344
Renae M RyanTransporter Biology Group, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia. renae.ryan@sydney.edu.au.ORCID http://orcid.org/0000-0002-8680-4610
The University of Sydney · AUUniversity of Illinois Urbana-Champaign · USVictor Chang Cardiac Research Institute · AU

Funding

WHOLE CELL SIMULATIONP41GM104601 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI TAJKHORSHID, EMAD · 2012 to 2021
$19.0M
System-Level Simulation of a Bioenergetic MembraneR01GM067887 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI TAJKHORSHID, EMAD · 2003 to 2018
$4.0M
NIGMS NIH HHS P41 GM104601NIGMS NIH HHS R01 GM067887
6 · The paper itself

Abstract

Glutamate is the most abundant excitatory neurotransmitter in the central nervous system, and its precise control is vital to maintain normal brain function and to prevent excitotoxicity

Indexed as

Hydrophobic and Hydrophilic InteractionsAmino Acid Transport System X-AGAnimalsBrainChloride ChannelsChloridesCryoelectron MicroscopyCrystallography, X-RayExcitatory Amino Acid Transporter 1FemaleGlutamic AcidHumansModels, MolecularMutationOocytesProtein ConformationAmino Acid Transport System X-AGChloride ChannelsChloridesExcitatory Amino Acid Transporter 1Glutamic AcidSLC1A3 protein, human

Identifiers

PMID33597752
PMCPMC7954978
OpenAlexW3131300525

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.