Evidence map›Paper›PMID 33597728›Full record

ArticleLeukemia2021

Selective elimination of immunosuppressive T cells in patients with multiple myeloma.

Mohamed H S Awwad, Abdelrahman Mahmoud, Heiko Bruns, Hakim Echchannaoui, Katharina Kriegsmann, Raphael Lutz, Marc S Raab, Uta Bertsch, Markus Munder, Anna Jauch and 13 more

Open access · hybridAbstract read
In one paragraph

Article in Leukemia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 57 citations in OpenAlex.

  1. Trial
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  6. Article
  7. Review
  8. SLAMF7 (CD319) on activated CD8Cell death and differentiation · 2025
    Article
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  11. Article
  12. Article
  13. Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 10 institutions in 1 country.

Mohamed H S AwwadDepartment of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.
Abdelrahman MahmoudDivision of Applied Bioinformatics, German Cancer Research Center, Heidelberg, Germany.
Heiko BrunsDepartment of Hematology and Oncology, Erlangen University Hospital, Erlangen, Germany.
Hakim EchchannaouiThird Department of Medicine, University Cancer Center (UCT), University Medical Center (UMC) of the Johannes Gutenberg University, Erlangen, Germany.
Katharina KriegsmannDepartment of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.
Raphael LutzDepartment of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.
Marc S RaabDepartment of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.
Uta BertschDepartment of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.
Markus MunderThird Department of Medicine, University Cancer Center (UCT), University Medical Center (UMC) of the Johannes Gutenberg University, Erlangen, Germany.
Anna JauchInstitute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany.
Katja WeiselDepartment of Oncology, Hematology and BMT, University Medical Center of Hamburg-Eppendorf, Hamburg, Germany.
Bettina MaierDepartment of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.
Niels WeinholdDepartment of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.
Hans Jürgen SalwenderAsklepios Tumorzentrum Hamburg, AK Altona and AK St. Georg, Hamburg, Germany.
Volker EcksteinDepartment of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.
Mathias HänelDepartment of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany.
Roland FenkDepartment of Hematology, Oncology and Clinical Immunology, Düsseldorf University, Hamburg, Germany.
Jan DürigDepartment of Hematology, Essen University, Hamburg, Germany.
Benedikt BrorsDivision of Applied Bioinformatics, German Cancer Research Center, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5940-3101
Axel BennerDivision of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Carsten Müller-TidowDepartment of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-7166-5232
Hartmut GoldschmidtDepartment of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-0961-0035
Michael HundemerDepartment of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany. michael.hundemer@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-5596-2405
Heidelberg University · DEGerman Cancer Research Center · DEJohannes Gutenberg University Mainz · DEAsklepios Klinik Altona · DEEssen University Hospital · DEEuropean Molecular Biology Organization · DEHeinrich Heine University Düsseldorf · DEKlinikum Chemnitz · DEUniversität Hamburg · DEUniversitätsklinikum Erlangen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elimination of suppressive T cells may enable and enhance cancer immunotherapy. Here, we demonstrate that the cell membrane protein SLAMF7 was highly expressed on immunosuppressive CD8

Indexed as

AdultAgedAnimalsAntibodies, Monoclonal, HumanizedAntineoplastic AgentsApoptosisCell ProliferationFemaleHumansLymphocyte DepletionMaleMiceMice, Inbred NODMice, SCIDMiddle AgedMultiple MyelomaAntibodies, Monoclonal, HumanizedAntineoplastic AgentselotuzumabSignaling Lymphocytic Activation Molecule FamilySLAMF7 protein, human

Identifiers

PMID33597728
PMCPMC8410603
OpenAlexW3132017193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.