ArticleJournal of exposure science & environmental epidemiology2021
Early-life exposure to aluminum and fine motor performance in infants: a longitudinal study.
Article in Journal of exposure science & environmental epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Selenium and zinc alleviate quaternary metal mixture -induced neurotoxicity in rats by inhibiting oxidative damage and modulating the expressions of NF-kB and Nrf2/Hmox-1 pathway.IBRO neuroscience reports · 2023Article
- Neonatal hepatitis B vaccination: Reevaluating timing and adjuvants for enhanced safety and effectiveness.Pediatric discovery · 2023Review
- Sex differences in the association between plasma polyunsaturated fatty acids levels and moderate-to-severe plaque psoriasis severity: a cross-sectional and longitudinal study.Journal of translational medicine · 2023Article
- Geographic differences in exposures to metals and essential elements in pregnant women living in Suriname.Journal of exposure science & environmental epidemiology · 2023Article
- Maternal and Newborn Blood Aluminum Levels and Neurodevelopment of Infants: Is there a Need for Concern?Indian journal of clinical biochemistry : IJCB · 2023Article
- Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural Bangladesh.Environment international · 2022Article
- COVID-19 Pandemic Effects on Neurodevelopment?-Reply.JAMA pediatrics · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAluminum (Al) is a well-established neurotoxicant. However, little is known about its effects on the neurodevelopment of infants.
objectivesTo examine early-life exposure to Al in relation to neurodevelopment in healthy infants.
methodsNail Al concentrations were measured among 747 newborn babies within 6 months of delivery in the Shanghai Birth Cohort. Neurodevelopment was assessed using Ages and stages questionnaire (third edition, ASQ-3) at ages 6 and 12 months. General linear regression models were performed to estimate the associations between Al concentrations and ASQ-3 scores.
resultsAfter adjustment for potential confounders, early-life exposure to Al was not associated with any neurodevelopmental performance at age 6 months. However, Al level was associated with an increased risk of having a low fine motor score (quartile 4 vs. quartile 1, mean difference (MD): -1.63; 95% confidence interval (CI): -3.22, -0.05; P-trend < 0.01) at 12 months. No association was found for communication, gross motor, problem-solving, or personal-social score at 12 months. SIGNIFICANCE: Early-life exposure to Al may be associated with poor fine motor skills in a dose-response manner among apparently healthy infants at age 12 months.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.