ArticleCommunications biology2021
The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2.
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Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57citing papers in PubMed
9.1field-weighted citation impact, top 1% of its field
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Who cites it
57 citing papers in PubMed, 95 citations in OpenAlex.
- Regulated degradation of KCC2, a potassium-chloride co-transporter required for synaptic transmission and neurodevelopment.Channels (Austin, Tex.) · 2026Review
- Comparative Evolution of SLC12 Transporters in Tilapias and Salinity-Responsive Expression in Nile Tilapia.International journal of molecular sciences · 2026Article
- Exploring and translating novel approaches targeting the choroid plexus for the treatment of hydrocephalus: a literature review.Fluids and barriers of the CNS · 2026Review
- Structural basis for the ion selectivity of potassium-chloride cotransporter KCC4 revealed by cryo-EM titration.Biophysics reports · 2026Article
- Sheep erythrocyte potassium locus highlights MYADM family regulation of electroneutral potassium chloride cotransporters (KCC).BMC genomics · 2026Article
- Chloride Homeostasis Failure in Human Disease: KCC2/NKCC1 Microdomain Dysfunction as a Driver of Cortical Network Collapse.International journal of molecular sciences · 2026Review
- Enhancing KCC2 function reduces interictal activity and prevents seizures in temporal lobe epilepsy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Biophysical characterization and ion transport with cell-based and proteoliposome reconstitution assays of invertebrate KFEBS open bio · 2025Article
- Inactivation mechanisms of NaCommunications biology · 2025Article
- Metabolic Energy is Stored in a Homeostatic Trans-Membrane Water Barochemical Gradient.The Journal of membrane biology · 2025Article
- VCP controls KCC2 degradation through FAF1 recruitment and accelerates emergence from anesthesia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Highly conserved ion binding sites are not all functionally relevant in mouse KCC4.Frontiers in molecular biosciences · 2025Article
- Inflammation and vasopressin hypersecretion in aging.Frontiers in endocrinology · 2025Review
- Protein Structural Modeling and Transport Thermodynamics Reveal That Plant Cation-Chloride Cotransporters Mediate Potassium-Chloride Symport.International journal of molecular sciences · 2024Article
- Intraventricular haemorrhage in premature infants: the role of immature neuronal salt and water transport.Brain : a journal of neurology · 2024Article
- Regulation of brain fluid volumes and pressures: basic principles, intracranial hypertension, ventriculomegaly and hydrocephalus.Fluids and barriers of the CNS · 2024Review
- Navigating the multifaceted intricacies of the NaPhysiological reviews · 2024Review
- A Futile Cycle?: Tissue Homeostatic Trans-Membrane Water Co-Transport: Kinetics, Thermodynamics, Metabolic Consequences.bioRxiv : the preprint server for biology · 2024Article
- The expression system influences stability, maturation efficiency, and oligomeric properties of the potassium-chloride co-transporter KCC2.Neurochemistry international · 2024Article
- Hypernegative GABAThe journal of pain · 2024Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Sensen Zhang *Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.ORCID 0000-0001-8827-3959
Jun Zhou *Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.ORCID 0000-0002-6603-3767
Yuebin Zhang *State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.ORCID 0000-0001-8174-7189
Tianya Liu *Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.ORCID 0000-0002-5371-6497
Perrine Friedel *Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4094-0369
Wei ZhuoMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.ORCID 0000-0003-0832-5187
Suma SomasekharanDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-4694-8860
Kasturi RoyDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2504-3114
Laixing ZhangMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.ORCID 0000-0001-9552-3848
Yang LiuMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.
Xianbin MengMOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, China.
Haiteng DengMOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, China.
Wenwen ZengCenter for Life Sciences, Institute for Immunology and School of Medicine, Tsinghua University, Beijing, China.ORCID 0000-0001-8544-3318
Guohui LiState Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China. ghli@dicp.ac.cn.ORCID 0000-0001-8223-705X
Biff ForbushDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA. biff.forbush@yale.edu.ORCID 0000-0001-5250-4057
Maojun YangMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China. maojunyang@tsinghua.edu.cn.ORCID 0000-0002-6798-3094
Center for Life Sciences · CNYale University · USDalian Institute of Chemical Physics · CNTsinghua University · CN
Funding
The Regulation of Renal Epithelial Cell Junction Assembly and PolarizationP01DK017433 · NIDDK · YALE UNIVERSITY · PI FORBUSH, BLISS · 1986 to 2018
$29.5MDiagnosing and Targeting Mechanisms of Diuretic Resistance in Heart FailureR01HL128973 · NHLBI · YALE UNIVERSITY · PI TESTANI, JEFFREY M · 2015 to 2019
$3.8MNHLBI NIH HHS R01 HL128973NIDDK NIH HHS P01 DK017433
Abstract
NKCC and KCC transporters mediate coupled transport of Na
Indexed as
AnimalsAnionsBinding SitesCationsCryoelectron MicroscopyHEK293 CellsHumansIon Channel GatingIon TransportK Cl- CotransportersMolecular Dynamics SimulationPhosphorylationProtein BindingProtein ConformationSf9 CellsSolute Carrier Family 12, Member 2AnionsCationsK Cl- CotransportersSLC12A2 protein, humanSolute Carrier Family 12, Member 2Symporters
Identifiers
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.