ArticleScientific reports2021
Complex precursor structures of cytolytic cupiennins identified in spider venom gland transcriptomes.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 9 citations in OpenAlex.
- Combating Antibiotic Resistance: Mechanisms, Multidrug-Resistant Pathogens, and Novel Therapeutic Approaches: An Updated Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Article
- Venom-gland transcriptomics and venom proteomics of the Tibellus oblongus spider.Scientific data · 2023Article
- Transcriptome analysis of the spiderThe journal of venomous animals and toxins including tropical diseases · 2023Article
- Molecular Diversity of Linear Peptides Revealed by Transcriptomic Analysis of the Venom Gland of the SpiderToxins · 2022Article
- Identifying novel antimicrobial peptides from venom gland of spiderFrontiers in microbiology · 2022Article
- Linear Peptides-A Combinatorial Innovation in the Venom of Some Modern Spiders.Frontiers in molecular biosciences · 2021Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Analysis of spider venom gland transcriptomes focuses on the identification of possible neurotoxins, proteins and enzymes. Here, the first comprehensive transcriptome analysis of cupiennins, small linear cationic peptides, also known as cytolytic or antimicrobial peptides, is reported from the venom gland transcriptome of Cupiennius salei by 454- and Illumina 3000 sequencing. Four transcript families with complex precursor structures are responsible for the expression of 179 linear peptides. Within the transcript families, after an anionic propeptide, cationic linear peptides are separated by anionic linkers, which are transcript family specific. The C-terminus of the transcript families is characterized by a linear peptide or truncated linkers with unknown function. A new identified posttranslational processing mechanism explains the presence of the two-chain CsTx-16 family in the venom. The high diversity of linear peptides in the venom of a spider and this unique synthesis process is at least genus specific as verified with Cupiennius getazi.
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