ArticleScientific reports2021
Prenatal and postnatal maternal anxiety and amygdala structure and function in young children.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Association of prenatal depression and anxiety with cortical development and behavioral outcomes in 8-year-old children.Journal of affective disorders · 2026Article
- Neonatal amygdala and fear processing across early childhood.European child & adolescent psychiatry · 2026Article
- Article
- Maternal mood entropy and children's hippocampal development: Enduring versus transient effects.Development and psychopathology · 2026Article
- COVID-19 Pandemic-Related Prenatal Distress and Infant Functional Brain Development.JAACAP open · 2025Article
- The association between prenatal maternal anxiety, infant brain volumes, and temperament during the COVID-19 pandemic.Translational psychiatry · 2025Article
- Maternal depressive symptoms in childhood and offspring brain cortical and subcortical volumetric change: A repeated imaging study from age 4-10 years.Developmental cognitive neuroscience · 2025Article
- Examining the association between maternal prenatal psychiatric disorders and behavioural problems among offspring in early childhood: population-based study.BJPsych open · 2025Article
- Neurodevelopmental Pathways from Temperamental Fear to Anxiety.Current topics in behavioral neurosciences · 2025Review
- Havening: a psycho-sensory therapy for enhancing emotional resilience and psycho-emotional wellbeing across the perinatal period.Frontiers in global women's health · 2025Article
- The impact of perceived caregiver anxiety and stress during childhood on late-life depression: evidence from the China Health and Retirement Longitudinal Study.Frontiers in psychiatry · 2025Article
- Maternal prenatal social disadvantage and neonatal functional connectivity: Associations with psychopathology symptoms at age 12 months.Developmental psychology · 2024Article
- Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy.Molecular psychiatry · 2024Review
- Modality-specific effects of threat on self-motion perception.BMC biology · 2024Article
- Article
- Maternal anxiety during pregnancy is associated with weaker prefrontal functional connectivity in adult offspring.Brain imaging and behavior · 2023Article
- Specificity of associations between parental psychopathology and offspring brain structure.Psychiatry research. Neuroimaging · 2023Article
- Lifelong effects of prenatal and early postnatal stress on the hippocampus, amygdala, and psychological states of Holocaust survivors.Scientific reports · 2023Article
- Postnatal maternal distress, infant subcortical brain macrostructure and emotional regulation.Psychiatry research. Neuroimaging · 2023Article
- Amygdala's T1-weighted image radiomics outperforms volume for differentiation of anxiety disorder and its subtype.Frontiers in psychiatry · 2023Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Anxiety symptoms are relatively common during pregnancy and are associated with behavioural problems in children. The amygdala is involved in emotion regulation, and its volume and function are associated with exposure to prenatal maternal depression. The associations between perinatal maternal anxiety and children's amygdala structure and function remain unclear. The objective of this study was to determine associations between prenatal and postnatal maternal anxiety and amygdala structure and function in children. Maternal anxiety was measured during the second trimester of pregnancy and 12 weeks postpartum. T1-weighted anatomical data and functional magnetic resonance imaging data were collected from 54 children (25 females), between the ages of 3-7 years. Amygdala volume was calculated and functional connectivity maps were created between the amygdalae and the rest of the brain. Spearman correlations were used to test associations between amygdala volume/functional connectivity and maternal anxiety symptoms, controlling for maternal depression symptoms. Second trimester maternal anxiety symptoms were negatively associated with functional connectivity between the left amygdala and clusters in bilateral parietal regions; higher maternal anxiety was associated with increased negative connectivity. Postnatal maternal anxiety symptoms were positively associated with child amygdala volume, but this finding did not remain significant while controlling for total brain volume. These functional connectivity differences may underlie behavioral outcomes in children exposed to maternal anxiety during pregnancy.
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