ArticleNature communications2021
Bedside functional monitoring of the dynamic brain connectivity in human neonates.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Microvascular ultrasound imaging of the neonatal brain: a scoping review.European journal of pediatrics · 2026Article
- Ultrafast ultrasound imaging reveals altered cerebral blood flow in newborn rats with hypoxic-ischemic encephalopathy.Pediatric research · 2026Article
- Task-free functional connectivity changes before and after hyper- and hypoglycemia in very preterm neonates.Neurophotonics · 2026Article
- Functional ultrasound imaging in preclinical brain stimulation: from multimodal readouts to closed-loop neuromodulation.Frontiers in neuroscience · 2026Review
- Ketamine-induced static and dynamic functional connectivity changes are modulated by opioid receptors and biological sex in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Imaging the brain by traversing the skull with light and sound.Nature biomedical engineering · 2025Review
- Human spinal cord activation during filling and emptying of the bladder.Nature communications · 2025Article
- Microvascular Ultrasound Imaging in the Neonatal Brain: From Advanced Doppler to Super-Resolution.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Review
- Development of brain metastable dynamics during the equivalent of the third gestational trimester.Developmental cognitive neuroscience · 2025Review
- Rapid Eye Movements in Sleep Furnish a Unique Probe into the Ontogenetic and Phylogenetic Development of the Visual Brain: Implications for Autism Research.Brain sciences · 2025Review
- Physio-fUS: a tissue-motion based method for heart and breathing rate assessment in neurofunctional ultrasound imaging.EBioMedicine · 2025Article
- Functional ultrasound (fUS) detects mild cerebral alterations using canonical correlation analysis denoising and dynamic functional connectivity analysis.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional Ultrasound Imaging of Auditory Responses in Comatose Patients.Research (Washington, D.C.) · 2025Article
- Characterizing the temporal dynamics and maturation of brain activity during sleep: An EEG microstate study in preterm and full-term infants.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Sleep state-dependent development of resting-state functional connectivity during the preterm period.Sleep · 2024Article
- Non-invasive 4D transcranial functional ultrasound and ultrasound localization microscopy for multimodal imaging of neurovascular response.Scientific reports · 2024Article
- Functional ultrasound and brain connectivity reveal central nervous system compromise in Trembler-J mice model of Charcot-Marie-Tooth disease.Scientific reports · 2024Article
- Dual-modal Photoacoustic and Ultrasound Imaging: from preclinical to clinical applications.Frontiers in photonics · 2024Article
- Mapping Pharmacologically Evoked Neurovascular Activation and Its Suppression in a Rat Model of Tremor Using Functional Ultrasound: A Feasibility Study.Sensors (Basel, Switzerland) · 2023Article
- Doppler Ultrasound Flow Reversal in the Superior Sagittal Sinus to Detect Cerebral Venous Congestion in Vein of Galen Malformation.AJNR. American journal of neuroradiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinicians have long been interested in functional brain monitoring, as reversible functional losses often precedes observable irreversible structural insults. By characterizing neonatal functional cerebral networks, resting-state functional connectivity is envisioned to provide early markers of cognitive impairments. Here we present a pioneering bedside deep brain resting-state functional connectivity imaging at 250-μm resolution on human neonates using functional ultrasound. Signal correlations between cerebral regions unveil interhemispheric connectivity in very preterm newborns. Furthermore, fine-grain correlations between homologous pixels are consistent with white/grey matter organization. Finally, dynamic resting-state connectivity reveals a significant occurrence decrease of thalamo-cortical networks for very preterm neonates as compared to control term newborns. The same method also shows abnormal patterns in a congenital seizure disorder case compared with the control group. These results pave the way to infants' brain continuous monitoring and may enable the identification of abnormal brain development at the bedside.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.