Evidence map›Paper›PMID 33597509›Full record

ReviewNPJ Regenerative medicine2021

Self-assembling peptide scaffolds in the clinic.

Fabrizio Gelain, Zhongli Luo, Marika Rioult, Shuguang Zhang

Abstract readReview
In one paragraph

Review in NPJ Regenerative medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Article
  2. Rheological Modeling to Assess the Gelation Kinetics of Mono- and Multicomponent Supramolecular Hydrogels.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026
    Article
  3. Review
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  8. A Novel Cell-Penetrating Lipopeptide for DNA Binding, Self-Assembly, and Delivery Into HeLa and Pluripotent Stem Cells.Journal of peptide science : an official publication of the European Peptide Society · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Backbone Protecting Groups for Enhanced Peptide and Protein Synthesis.Angewandte Chemie (International ed. in English) · 2025
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fabrizio Gelain *Institute for Stem-Cell Biology, Regenerative Medicine and Innovative Therapies (ISBREMIT), IRCCS Casa Sollievo della Sofferenza, 71013, San Giovanni Rotondo, Italy. f.gelain@css-mendel.it.ORCID http://orcid.org/0000-0002-2624-5853
Zhongli Luo *College of Basic Medical Sciences, Molecular Medicine and Cancer Research Centre, Chongqing Medical University, Chongqing, 400016, China. Zhongliluo@163.com.
Marika Rioult3-D Matrix Inc., Needham, MA, 02494, USA.
Shuguang ZhangLaboratory of Molecular Architecture, Media Lab, Massachusetts Institute of Technology, Cambridge, MA, 02139-4307, USA. Shuguang@MIT.EDU.ORCID http://orcid.org/0000-0002-3856-3752

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Well-defined scaffold hydrogels made of self-assembling peptides have found their way into clinical products. By examining the properties and applications of two self-assembling peptides-EAK16 and RADA16-we highlight the potential for translating designer biological scaffolds into commercial products.

Identifiers

PMID33597509
PMCPMC7889856

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.