Evidence map›Paper›PMID 33597309›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

The zebrafish

Charlotte D Koopman, Jessica De Angelis, Swati P Iyer, Arie O Verkerk, Jason Da Silva, Geza Berecki, Angela Jeanes, Gregory J Baillie, Scott Paterson, Veronica Uribe and 10 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Fins, fur, and wings: the study of Tmem161b across species, and what it tells us about its function in the heart.Mammalian genome : official journal of the International Mammalian Genome Society · 2023
    Review
  6. Review
  7. Article
  8. TMEM161B modulates radial glial scaffolding in neocortical development.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Article
  10. Article
  11. Modeling Human Cardiac Arrhythmias: Insights from Zebrafish.Journal of cardiovascular development and disease · 2022
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 2 countries.

Charlotte D KoopmanDepartment of Cardiac Development and Genetics, Hubrecht Institute, University Medical Centre Utrecht, Utrecht 3584 CT, The Netherlands.
Jessica De AngelisInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Swati P IyerInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Arie O VerkerkDepartment of Medical Biology, Amsterdam University Medical Centre, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0003-2140-834X
Jason Da SilvaInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Geza BereckiThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0002-8664-6325
Angela JeanesInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Gregory J BaillieInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-6130-250X
Scott PatersonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Veronica UribeDepartment of Physiology, The University of Melbourne, Parkville, VIC 3010, Australia.
Ophelia V EhrlichDepartment of Physiology, The University of Melbourne, Parkville, VIC 3010, Australia.
Samuel D RobinsonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Laurence GarricDepartment of Cardiac Development and Genetics, Hubrecht Institute, University Medical Centre Utrecht, Utrecht 3584 CT, The Netherlands.
Steven PetrouThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia.
Cas SimonsInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Irina VetterInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-3594-9588
Benjamin M HoganInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Teun P de BoerDepartment of Medical Physiology, Division of Heart & Lungs, University Medical Center, Utrecht 3584 CM, The Netherlands.ORCID 0000-0002-0561-6491
Jeroen BakkersDepartment of Cardiac Development and Genetics, Hubrecht Institute, University Medical Centre Utrecht, Utrecht 3584 CT, The Netherlands.ORCID 0000-0002-9418-0422
Kelly A SmithInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia; kelly.smith1@unimelb.edu.au.ORCID 0000-0002-8283-9760
The University of Queensland · AUThe University of Melbourne · AUUniversity Medical Center Utrecht · NL

Funding

High-throughput targeted mutagenesis of mouse stem cell linesU01HG004080 · NHGRI · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI DE JONG, PIETER J. · 2006 to 2010
$28.1M
Production of Targeted Null Mutations for 10,000 Genes in C57BL/6 ES CellsU01HG004085 · NHGRI · REGENERON PHARMACEUTICALS, INC. · PI VALENZUELA, DAVID MANUEL · 2006 to 2010
$25.3M
NHGRI NIH HHS U01 HG004080NHGRI NIH HHS U01 HG004085
6 · The paper itself

Abstract

The establishment of cardiac function in the developing embryo is essential to ensure blood flow and, therefore, growth and survival of the animal. The molecular mechanisms controlling normal cardiac rhythm remain to be fully elucidated. From a forward genetic screen, we identified a unique mutant,

Indexed as

MutationAction PotentialsAnimalsAnimals, Genetically ModifiedArrhythmias, CardiacBase SequenceCalciumConserved SequenceDisease Models, AnimalEmbryo, MammalianEmbryo, NonmammalianGene Expression Regulation, DevelopmentalGenes, LethalHeartHeart RateIon TransportCalciumMembrane ProteinsPotassiumTmem161b protein, mouseTmem161b protein, zebrafishZebrafish Proteinsarrhythmiacardiacforward geneticsmousezebrafish

Identifiers

PMID33597309
PMCPMC7936323
OpenAlexW3133177974

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.