ArticleScience translational medicine2021
Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy.
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Mitochondrial dysfunction in cardiovascular disease: Towards exercise regulation of mitochondrial function.Frontiers in physiology · 2023Pooled it
- Machine learning models enhance detection of arrhythmogenic right ventricular cardiomyopathy.Machine learning. Health · 2026Article
- Review
- Review
- Cardiomyocyte-Specific Plakophilin-2 Loss Is Sufficient to Induce Aging and Senescence of Nonmyocytes: Relevance to Arrhythmogenic Cardiomyopathy.Journal of the American Heart Association · 2026Article
- Calpain-1 Potentiates Periodontal Regeneration via PHLPP1-ERK-Driven Osteogenesis in Periodontal Ligament Stem Cells.International dental journal · 2026Article
- Increased Intermembrane Space [CaCirculation research · 2025Article
- TRPA1 activation prompts lysosome-mediated Nrf2 degradation enhancing the killing of colorectal cancer cells.Redox biology · 2025Article
- Acute binge alcohol increases risk of arrhythmias and myocardial fibrosis in a mouse model of arrhythmogenic cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2025Article
- Molecular Pathogenesis of Arrhythmogenic Cardiomyopathy: Mechanisms and Therapeutic Perspectives.Biomolecules · 2025Review
- Desmoglein-2 deficiency results in cardiac dysfunction by compromising both Z-disc- and intercalated disc-mediated mechanotransduction.bioRxiv : the preprint server for biology · 2025Article
- PANoptosis in cancer: molecular mechanisms and therapeutic potential.Cancer gene therapy · 2025Review
- Machine Learning Models Enhance Prediction of Arrhythmogenic Right Ventricular Cardiomyopathy.medRxiv : the preprint server for health sciences · 2025Article
- The regulatory role of exercise in heart failure and myocardial energy metabolism: A review.Biomolecules & biomedicine · 2025Review
- Qualitative analysis of experiences, burdens, and needs among patients with hypertrophic cardiomyopathy in Japan.Future cardiology · 2025Observational
- Mitochondrial Quality Control in Health and Disease.MedComm · 2025Review
- Exercise Prescription in Arrhythmogenic Cardiomyopathy: Finding the Right Balance Between Risks and Benefits.Journal of the American Heart Association · 2025Review
- OPA1 mutations in dominant optic atrophy: domain-specific defects in mitochondrial fusion and apoptotic regulation.Journal of translational medicine · 2025Article
- Particulate matter and co-occurring genetic risk induce oxidative stress and cardiac and brain Alzheimer's pathology.Communications biology · 2025Article
- Cardiomyocyte-specific Piezo1 deficiency mitigates ischemia-reperfusion injury by preserving mitochondrial homeostasis.Redox biology · 2025Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
26 authors at 8 institutions in 4 countries.
Stephen P ChelkoDepartment of Biomedical Sciences, Florida State University, Tallahassee, FL 32306, USA. stephen.chelko@med.fsu.edu npaoloc1@jhmi.edu.ORCID 0000-0003-1675-5945
Gizem KeceliDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-9562-7994
Andrea CarpiDepartment of Biomedical Sciences, University of Padova, Padova 35122, Italy.
Nunzianna DotiInstitute of Biostructures and Bioimaging, CNR, Naples 80134, Italy.ORCID 0000-0003-2952-6658
Jacopo AgrimiDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Angeliki AsimakiMolecular and Clinical Sciences Research Institute, St. George's, University of London, London WC1E 6BS, UK.ORCID 0000-0001-9886-6870
Carlos Bueno BetiMolecular and Clinical Sciences Research Institute, St. George's, University of London, London WC1E 6BS, UK.
Matthew MiyamotoDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-2140-6769
Nuria Amat-CodinaDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Djahida BedjaDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-1716-6835
An-Chi WeiDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-7927-1636
Brittney MurrayDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-7870-8584
Crystal TichnellDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Chulan KwonDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Hugh CalkinsDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Cynthia A JamesDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-8040-4600
Brian O'RourkeDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-5548-4853
Marc K HalushkaDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-7112-7389
Edon MelloniDepartment of Medicine, University of Genova, Genova 16126, Italy.
Jeffrey E SaffitzDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 20115, USA.ORCID 0000-0001-8568-9457
Daniel P JudgeDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-3407-0248
Menotti RuvoInstitute of Biostructures and Bioimaging, CNR, Naples 80134, Italy.ORCID 0000-0001-5997-756X
Richard N KitsisDepartments of Medicine and Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0003-1395-9694
Peter AndersenDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-3971-0467
Fabio Di LisaDepartment of Biomedical Sciences, University of Padova, Padova 35122, Italy.
Nazareno PaolocciDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. stephen.chelko@med.fsu.edu npaoloc1@jhmi.edu.ORCID 0000-0001-7011-997X
Johns Hopkins University · USUniversity of Padua · ITInstitute of Biostructure and Bioimaging · ITSt George's, University of London · GBAlbert Einstein College of Medicine · USBeth Israel Deaconess Medical Center · USFlorida State University · USUniversity of Genoa · IT
Funding
IN VIVO MURINE CARDIAC ENERGY METABOLISM AND FUNCTIONR01HL063030 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WEISS, ROBERT G · 2000 to 2018
$4.9MTranslational Aging Research Training ProgramT32AG058527 · NIA · JOHNS HOPKINS UNIVERSITY · PI Peter M. Abadir, Esther Seunghee Oh · 2018 to 2026
$4.0MBDNF TrkB- and beta-AR signals in ischemic and non-ischemic cardiomyopathyR01HL136918 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PAOLOCCI, NAZARENO · 2018 to 2021
$2.7MChaperone-Mediated Autophagy in Normal Cardiac Biology and Heart FailureR01HL138475 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KITSIS, RICHARD N · 2017 to 2020
$2.4MTranscriptomic Entropy to Quantify Maturation of PSC-Derived CardiomyocytesR01HL156947 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KIM, DEOK-HO, KWON, CHULAN · 2021 to 2024
$2.3MTargeting Metabo-Redox Network Vulnerability in Heart Failure and Sudden DeathR01HL134821 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI FOSTER, D BRIAN, O'ROURKE, BRIAN · 2018 to 2021
$2.1MMolecular Determinants of Mitochondrial Instability and ArrhythmiasR01HL137259 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI AKAR, FADI GABRIEL, O'ROURKE, BRIAN · 2017 to 2020
$2.0MRegulation of Cardiac Progenitor MaintenanceR01HD086026 · NICHD · JOHNS HOPKINS UNIVERSITY · PI KWON, CHULAN · 2016 to 2020
$1.6MNHLBI NIH HHS R01 HL063030NHLBI NIH HHS R01 HL134821NHLBI NIH HHS R01 HL136918NHLBI NIH HHS R01 HL137259NHLBI NIH HHS R01 HL138475NHLBI NIH HHS R01 HL156947NIA NIH HHS T32 AG058527NICHD NIH HHS R01 HD086026
Abstract
Myocyte death occurs in many inherited and acquired cardiomyopathies, including arrhythmogenic cardiomyopathy (ACM), a genetic heart disease plagued by the prevalence of sudden cardiac death. Individuals with ACM and harboring pathogenic desmosomal variants, such as desmoglein-2 (
Indexed as
Apoptosis Inducing FactorCalpainCardiomyopathiesPhysical Conditioning, AnimalAnimalsCell DeathMiceMitochondriaMyocytes, CardiacApoptosis Inducing FactorCalpainCapn1 protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.