Evidence map›Paper›PMID 33597201›Full record

ArticleBiology open2021

A zebrafish forward genetic screen identifies an indispensable threonine residue in the kinase domain of PRKD2.

Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V Dedoussis, Susan F Steinberg, Panos Deloukas, Dimitris Beis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Panagiota GiardoglouZebrafish Disease Model lab, Biomedical Research Foundation Academy of Athens, Athens 115 27, Greece.
Despina BourneleZebrafish Disease Model lab, Biomedical Research Foundation Academy of Athens, Athens 115 27, Greece.
Misun ParkDepartment of Pharmacology, Columbia University, New York 100 27, USA.ORCID 0000-0002-9858-4408
Stavroula KanoniWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Clinical Pharmacology Centre, Queen Mary University of London, London, EC1M 6BQ, UK.
George V DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens 176 71, Greece.
Susan F SteinbergDepartment of Pharmacology, Columbia University, New York 100 27, USA.ORCID 0000-0002-2927-8570
Panos DeloukasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Clinical Pharmacology Centre, Queen Mary University of London, London, EC1M 6BQ, UK.
Dimitris BeisZebrafish Disease Model lab, Biomedical Research Foundation Academy of Athens, Athens 115 27, Greece dbeis@bioacademy.gr.ORCID 0000-0003-2579-7848
Academy of Athens · GRColumbia University · USQueen Mary University of London · GBHarokopio University of Athens · GR

Funding

British Heart Foundation RG/14/5/30893
6 · The paper itself

Abstract

Protein kinase D2 belongs to a family of evolutionarily conserved enzymes regulating several biological processes. In a forward genetic screen for zebrafish cardiovascular mutants, we identified a mutation in the

Indexed as

MutationProtein Interaction Domains and MotifsAmino Acid SequenceAmino Acid SubstitutionAnimalsEctopic Gene ExpressionEnzyme ActivationHeartHumansOrganogenesisPhenotypeProtein Kinase D2ThreonineZebrafishProtein Kinase D2ThreonineCardiac valvesCardiovascular developmentProtein kinase D2Zebrafish

Identifiers

PMID33597201
PMCPMC7969590
OpenAlexW3133278229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.