ArticleThe British journal of ophthalmology2023
Rebubbling and graft failure in Descemet membrane endothelial keratoplasty: a prospective Dutch registry study.
Article in The British journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Trial
- Preoperative and perioperative factors that predict graft failure 1 year after Descemet membrane endothelial keratoplasty.PloS one · 2026Article
- Anterior Chamber Inflammation and Descemet Membrane Endothelial Keratoplasty: An Anterior Segment-OCT-Based Analysis.Ophthalmology science · 2026Article
- Multivariate relationships between graft detachment after DMEK and twelve pre/perioperative factors.Scientific reports · 2025Article
- A Review of Outcomes of Descemet Membrane Endothelial Keratoplasty and Descemet Stripping Automated Endothelial Keratoplasty Interventions in Patients with Pre-Existing Glaucoma.Journal of clinical medicine · 2025Review
- Graft detachment rates in surgeon-cut and pre-cut tissue for DSAEK transported in different mediums.Acta ophthalmologica · 2025Article
- Corneal Characteristics After Small-Diameter DMEK Graft for Fuchs Corneal Dystrophy-Long-Term Observation.Journal of clinical medicine · 2025Article
- Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty in Saudi Patients.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Molecular Changes in Aqueous Humor Associated with Inflammation Following Cataract Surgery in Patients with Fuchs' Endothelial Corneal Dystrophy.Ophthalmology and therapy · 2025Article
- Effects of graft detachment on the central corneal thickness after uncomplicated Descemet membrane endothelial keratoplasty.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Comparison of rebubbling rate between preloaded endothelium-in and preloaded no-touch endothelium-out Descemet membrane endothelial keratoplasty transplantation.BMC ophthalmology · 2024Article
- Predictive factors for re-bubbling after DMEK: focus on the posterior corneal surface.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Potential applications of artificial intelligence in image analysis in cornea diseases: a review.Eye and vision (London, England) · 2024Review
- Surgical management of complicated Descemet's membrane detachment in corneas without prior endothelial keratoplasty.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Incidence and management of early postoperative complications in lamellar corneal transplantation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Review
- Article
- Graft Detachment after Descemet Membrane Endothelial Keratoplasty with and without Cataract Surgery.Ophthalmology science · 2022Article
- A machine learning approach to explore predictors of graft detachment following posterior lamellar keratoplasty: a nationwide registry study.Scientific reports · 2022Article
- Ability of routinely collected clinical factors to predict good visual results after primary Descemet membrane endothelial keratoplasty: a cohort study.BMC ophthalmology · 2022Article
- Outcomes of the advanced visualization in corneal surgery evaluation trial; a non-inferiority randomized control trial to evaluate the use of intraoperative OCT during Descemet membrane endothelial keratoplasty.Frontiers in ophthalmology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo identify risk factors for rebubbling, and early graft failure after Descemet membrane endothelial keratoplasty (DMEK).
methodsIn this prospective registry study, all consecutive DMEK procedures registered in the Netherlands Organ Transplant Registry were assessed (n=752). Univariable and multivariable analysis was performed using logistic regression. The effect of rebubbling on endothelial cell density was analysed using a linear mixed model.
results144 of 752 (19%) eyes underwent rebubbling. Rebubbling was successful in 101 eyes (70%). In eyes that underwent rebubbling, the graft failure rate was significantly higher than eyes that did not undergo rebubbling (30% vs 9%, respectively; OR: 4.28, 95% CI 2.72 to 6.73, p<0.001). In multivariable analysis, independent risk factors for rebubbling were surgical complication (OR: 2.28, 95% CI 1.20 to 4.33, p=0.012) and older recipient age (OR: 1.04 (per increase of 1 year), 95% CI 1.01 to 1.07, p=0.003). Risk factors for developing graft failure within 3 months were transplant before 2016 (OR: 3.32, 95% CI 1.87 to 5.90, p<0.001), and surgical complication (OR: 2.93, 95% CI 1.42 to 6.04, p=0.004). Throughout the study period, rebubbling and early graft failure were inversely related. Eyes that underwent rebubbling showed significantly lower endothelial cell densities at 3, 6 and 12 months compared with eyes that did not undergo rebubbling (all p<0.001).
conclusionsThis Dutch registry study identified independent risk factors for DMEK graft detachment leading to rebubbling, namely recipient age and surgical complication, and early graft failure, namely transplantation before 2016 and surgical complication. Rebubbling was associated with significantly higher endothelial cell loss in the first year after surgery.
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