Evidence map›Paper›PMID 33597191›Full record

ArticleDevelopment (Cambridge, England)2021

PRDM16 regulates a temporal transcriptional program to promote progression of cortical neural progenitors.

Li He, Jennifer Jones, Weiguo He, Bryan C Bjork, Jiayu Wen, Qi Dai

Open access · hybridAbstract read
In one paragraph

Article in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Evolution of CTCF binding sites in the human genome.Molecular biology and evolution · 2026
    Article
  2. Neural cell state modulation bybioRxiv : the preprint server for biology · 2026
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  10. Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex Development and Evidence for Dmrta2 Function in the Choroid Plexus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Li HeDepartment of Molecular Bioscience, the Wenner-Gren Institute, Stockholm University, 10691 Stockholm, Sweden.ORCID 0000-0002-4743-5410
Jennifer JonesDepartment of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Downers Grove, IL 60515, USA.
Weiguo HeDepartment of Molecular Bioscience, the Wenner-Gren Institute, Stockholm University, 10691 Stockholm, Sweden.ORCID 0000-0001-8929-7741
Bryan C BjorkDepartment of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Downers Grove, IL 60515, USA bbjork@midwestern.edu jiayu.wen@anu.edu.au qi.dai@su.se.ORCID 0000-0002-1245-091X
Jiayu WenDepartment of Genome Sciences, The John Curtin School of Medical Research, The Australian National University, 2601 Canberra, Australia bbjork@midwestern.edu jiayu.wen@anu.edu.au qi.dai@su.se.ORCID 0000-0003-1249-6456
Qi DaiDepartment of Molecular Bioscience, the Wenner-Gren Institute, Stockholm University, 10691 Stockholm, Sweden bbjork@midwestern.edu jiayu.wen@anu.edu.au qi.dai@su.se.ORCID 0000-0002-2082-0693
Stockholm University · SEMidwestern University · USAustralian National University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radial glia (RG) in the neocortex sequentially generate distinct subtypes of projection neurons, accounting for the diversity and complex assembly of cortical neural circuits. Mechanisms that drive the rapid and precise temporal progression of RG are beginning to be elucidated. Here, we reveal that the RG-specific transcriptional regulator PRDM16 promotes the transition of early to late phase of neurogenesis in the mouse neocortex. Loss of

Indexed as

AnimalsCell DifferentiationCell MovementChromatinDNA-Binding ProteinsEpendymoglial CellsGene Expression Regulation, DevelopmentalMiceNeocortexNeural Stem CellsNeurogenesisNeurogliaNeuronsSignal TransductionTranscription FactorsChromatinDNA-Binding ProteinsPrdm16 protein, mouseTranscription FactorsMouseNeocortexPRDM16Radial gliaTemporal identity

Identifiers

PMID33597191
PMCPMC7990860
OpenAlexW3129586235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.