ArticleBMJ open diabetes research & care2021
Spousal concordance in pathophysiological markers and risk factors for type 2 diabetes: a cross-sectional analysis of The Maastricht Study.
Article in BMJ open diabetes research & care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence of correlations between human partners based on systematic reviews and meta-analyses of 22 traits and UK Biobank analysis of 133 traits.Nature human behaviour · 2023Pooled it
- Familial Associations of Metabolic Syndrome and Its Interrelated Traits in Southwestern Indigenous Americans.The Journal of clinical endocrinology and metabolism · 2025Article
- Physical activity among Chinese pregnant women in the first trimester: A cross-sectional study.International journal of nursing sciences · 2025Article
- Partnership and marriage and risk of type 2 diabetes: a narrative review.Diabetologia · 2025Review
- Couples-based health behavior change interventions: A relationship science perspective on the unique opportunities and challenges to improve dyadic health.Comprehensive psychoneuroendocrinology · 2024Article
- What is the impact of one's chronic illness on his or her spouse's future chronic illness: a community-based prospective cohort study.BMC medicine · 2023Article
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15 authors.
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Abstract
introductionWe compared the degree of spousal concordance in a set of detailed pathophysiological markers and risk factors for type 2 diabetes to understand where in the causal cascade spousal similarities are most relevant. RESEARCH DESIGN AND
methodsThis is a cross-sectional analysis of couples who participated in The Maastricht Study (n=172). We used quantile regression models to assess spousal concordance in risk factors for type 2 diabetes, including four adiposity measures, two dimensions of physical activity, sedentary time and two diet indicators. We additionally assessed beta cell function and insulin sensitivity and glucose metabolism status with fasting and 2-hour plasma glucose and hemoglobin A1c.
resultsThe strongest spousal concordance (beta estimates) was observed for the Dutch Healthy Diet Index (DHDI) in men. A one-unit increase in wives' DHDI was associated with a 0.53 (95% CI 0.22 to 0.67) unit difference in men's DHDI. In women, the strongest concordance was for the time spent in high-intensity physical activity (HPA); thus, a one-unit increase in husbands' time spent in HPA was associated with a 0.36 (95% CI 0.17 to 0.64) unit difference in women's time spent in HPA. The weakest spousal concordance was observed in beta cell function indices.
conclusionsSpousal concordance was strongest in behavioral risk factors. Concordance weakened when moving downstream in the causal cascade leading to type 2 diabetes. Public health prevention strategies to mitigate diabetes risk may benefit from targeting spousal similarities in health-related behaviors and diabetes risk factors to design innovative and potentially more effective couple-based interventions.
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