Evidence map›Paper›PMID 33597149›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

The Butyrate-Producing Bacterium

Atsushi Hayashi, Hiroko Nagao-Kitamoto, Sho Kitamoto, Chang H Kim, Nobuhiko Kamada

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 87 citations in OpenAlex.

  1. Trial
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  12. Unravelling three-way interactions betweenJournal of medical microbiology · 2025
    Review
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  14. Microbiology spectrum · 2025
    Article
  15. Article
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  18. iMetaOmics · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Atsushi HayashiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0003-4060-2383
Hiroko Nagao-KitamotoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Sho KitamotoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0003-3597-6647
Chang H KimDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109; and.
Nobuhiko KamadaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109; nkamada@umich.edu.
University of Michigan · US

Funding

University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5M
The role of IL-1ß-inducing pathobionts in the pathogenesis of Crohn’s diseaseR01DK108901 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nobuhiko Kamada · 2017 to 2026
$3.8M
NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK108901
6 · The paper itself

Abstract

Short-chain fatty acids, such as butyrate, are major gut microbial metabolites that are beneficial for gastrointestinal health.

Indexed as

alpha-DefensinsAnimalsButyratesClostridioides difficileClostridium butyricumClostridium InfectionsColonInterferon-gammaInterleukin-17MiceMice, Inbred C57BLMice, KnockoutNeutrophilsReceptors, G-Protein-Coupledalpha-DefensinsButyratesFfar2 protein, mouseHCAR2 protein, humanInterferon-gammaInterleukin-17Receptors, G-Protein-Coupled

Identifiers

PMID33597149
PMCPMC7980534
OpenAlexW3130109427

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.