ArticleItalian journal of pediatrics2021
Incidence of urinary tract infection in neonates with significant indirect Hyperbilirubinemia of unknown etiology: case-control study.
Article in Italian journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Renal ultrasonography findings are associated with urinary tract infection in neonates with asymptomatic hyperbilirubinemia.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Phenotype-genotype discordance in antimicrobial resistance profiles of Gram-negative uropathogens recovered from catheter-associated urinary tract infections in Egypt.The Journal of antimicrobial chemotherapy · 2025Article
- Prenatal Diagnosis of Ductal Constriction in Normal Heart Anatomy-Are There Any Neonatal Consequences?Journal of clinical medicine · 2025Article
- Epidemiological insights into seasonal, sex‑specific and age‑related distribution of bacterial pathogens in urinary tract infections.Experimental and therapeutic medicine · 2024Article
- Risk factors for urinary tract infection in infants with unexplained hyperbilirubinemia: a single center case-control study.Frontiers in pediatrics · 2024Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
backgroundIndirect hyperbilirubinemia is frequently encountered during neonatal period. Although it has different causes, in some cases it can't be explained. Previous studies have illustrated that jaundice could be a major sign of urinary tract infection (UTI) in neonates. AIM OF THE WORK: We aimed to determine the association between UTI and significant unexplained neonatal indirect hyperbilirubinemia.
methodsThis prospective controlled study was performed on 150 neonates divided in two groups (100 as cases and 50 as controls) to investigate the incidence of UTI in neonates with significant unexplained hyperbilirubinemia. Urine sample was obtained using urine catheterization technique from neonates and full urine analysis was done and cases with pyuria had urine culture to confirm UTI. Immediate renal ultrasonography (USG) was performed for neonates with UTI.
resultsUTI incidence was 11% in cases while none of neonates in control group had UTI with statistical significance between cases and controls (P value < 0.05). The most common (36.4%) pathogen was Escherichia coli. Posterior urethral valve with mild hydronephrosis was diagnosed in 18.2% of UTI positive patients by renal ultrasonography.
conclusionIn neonates with unexplained indirect hyperbilirubinemia, UTI should be considered as a pathological cause.
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