Evidence map›Paper›PMID 33596669›Full record

ArticleCirculation research2021

Restructuring the Gut Microbiota by Intermittent Fasting Lowers Blood Pressure.

Huanan Shi, Bojun Zhang, Taylor Abo-Hamzy, James W Nelson, Chandra Shekar R Ambati, Joseph F Petrosino, Robert M Bryan, David J Durgan

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 102 citations in OpenAlex.

  1. Trial
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  8. Article
  9. Biologics for cardiovascular diseases: from bench to bedside.Signal transduction and targeted therapy · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Food as Medicine for Hypertension: Microbiota as Mediators.Hypertension (Dallas, Tex. : 1979) · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Diet, gut microbiota, and health: a review.Food science and biotechnology · 2025
    Review
  20. Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Huanan Shi *Department of Anesthesiology (H.S., B.Z., J.W.N., R.M.B., D.J.D.).
Bojun Zhang *Department of Anesthesiology (H.S., B.Z., J.W.N., R.M.B., D.J.D.).
Taylor Abo-HamzySchool of Health Professions (T.A.-H.).
James W NelsonDepartment of Anesthesiology (H.S., B.Z., J.W.N., R.M.B., D.J.D.).
Chandra Shekar R AmbatiAdvanced Technology Cores (C.S.R.A.).
Joseph F PetrosinoDepartment of Molecular Virology and Microbiology, The Alkek Center for Metagenomics and Microbiome Research (J.F.P.).
Robert M BryanDepartment of Anesthesiology (H.S., B.Z., J.W.N., R.M.B., D.J.D.).
David J DurganDepartment of Anesthesiology (H.S., B.Z., J.W.N., R.M.B., D.J.D.).
Baylor College of Medicine · USAdvanced Pharma · USInstitute of Metagenomics and Microbial Technologies (Slovenia) · SIIntegrated Oncology (United States) · USJisc · GBMGH Institute of Health Professions · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
Translational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Casey W Wright · 2019 to 2026
$14.7M
EXAMINING THE ROLE OF GUT DYSBIOSIS IN OBSTRUCTIVE SLEEP APNEA INDUCED HYPERTENSION.R01HL134838 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI DURGAN, DAVID J · 2018 to 2022
$2.0M
Gut Dysbiosis and Cerebral Small Vessel DiseaseR01NS102594 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI BRYAN, ROBERT M · 2018 to 2021
$1.6M
NCI NIH HHS P30 CA125123NHLBI NIH HHS R01 HL134838NIDDK NIH HHS P30 DK056338NIEHS NIH HHS P30 ES030285NINDS NIH HHS R01 NS102594
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AnimalsBile Acids and SaltsCecumCholic AcidDysbiosisFastingGastrointestinal MicrobiomeGerm-Free LifeHypotensionMetabolomeOleanolic AcidRandom AllocationRatsRats, Inbred SHRRats, Inbred WKYReceptors, G-Protein-CoupledBile Acids and SaltsCholic AcidGpbar1 protein, ratOleanolic AcidReceptors, G-Protein-Coupledbile acidsdysbiosisfastingmetabolomicsmicrobiota

Identifiers

PMID33596669
PMCPMC8085162
OpenAlexW3130466582

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.