Evidence map›Paper›PMID 33596666›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA-Induced VE-Cadherin Internalization.

Giulia De Rossi, Maria Vähätupa, Enrico Cristante, Samantha Arokiasamy, Sidath E Liyanage, Ulrike May, Laura Pellinen, Hannele Uusitalo-Järvinen, James W Bainbridge, Tero A H Järvinen and 1 more

Open access · bronzeAbstract readVideo-Audio Media
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

  1. Trial
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  7. Article
  8. Spatial and Functional Roles of Syndecans in Skin Wound Healing.International journal of molecular sciences · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Syndecans in hematopoietic cells and their niches.American journal of physiology. Cell physiology · 2024
    Review
  17. Article
  18. Article
  19. Endothelial glycocalyx in retina, hyperglycemia, and diabetic retinopathy.American journal of physiology. Cell physiology · 2023
    Review
  20. Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Giulia De RossiWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (G.D.R., S.A., J.R.W.).
Maria VähätupaFaculty of Medicine and Health Technology, Tampere University, Finland (M.V., U.M., L.P., H.U.-J., T.A.H.J.).
Enrico CristanteGenetics Department (E.C., S.E.L., J.W.B.), UCL Institute of Ophthalmology, London, United Kingdom.
Samantha ArokiasamyWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (G.D.R., S.A., J.R.W.).
Sidath E LiyanageGenetics Department (E.C., S.E.L., J.W.B.), UCL Institute of Ophthalmology, London, United Kingdom.
Ulrike MayFaculty of Medicine and Health Technology, Tampere University, Finland (M.V., U.M., L.P., H.U.-J., T.A.H.J.).
Laura PellinenFaculty of Medicine and Health Technology, Tampere University, Finland (M.V., U.M., L.P., H.U.-J., T.A.H.J.).
Hannele Uusitalo-JärvinenFaculty of Medicine and Health Technology, Tampere University, Finland (M.V., U.M., L.P., H.U.-J., T.A.H.J.).
James W BainbridgeGenetics Department (E.C., S.E.L., J.W.B.), UCL Institute of Ophthalmology, London, United Kingdom.
Tero A H JärvinenFaculty of Medicine and Health Technology, Tampere University, Finland (M.V., U.M., L.P., H.U.-J., T.A.H.J.).
James R WhitefordWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (G.D.R., S.A., J.R.W.).
Tampere University of Applied Sciences · FIInstitute of Ophthalmology · MXQueen Mary University of London · GB

Funding

Medical Research Council MR/K003003/1Versus Arthritis 19207Versus Arthritis 21177
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

Neovascularization, PathologicAnimalsAntigens, CDCadherin 5CadherinsCapillary PermeabilityChoroidal NeovascularizationDisease Models, AnimalEndothelial CellsFemaleHumansMacular DegenerationMaleMelanoma, ExperimentalMiceMice, Inbred C57BLAntigens, CDCadherin 5CadherinsKdr protein, mouseSdc4 protein, mouseSyndecan-4Vascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2cadherinsdiabetic retinopathypermeabilitysyndecansvascular endothelial growth factor A

Identifiers

PMID33596666
PMCPMC7613699
OpenAlexW3130217688

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.