Evidence map›Paper›PMID 33596663›Full record

ArticleCirculation. Cardiovascular quality and outcomes2021

Practical Application of Patient-Reported Health Status Measures for Transcatheter Valve Therapies: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapies Registry.

Vittal Hejjaji, David J Cohen, John D Carroll, Zhuokai Li, Pratik Manandhar, Sreekanth Vemulapalli, Adam J Nelson, Ali O Malik, Michael J Mack, John A Spertus and 1 more

Abstract read
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. 2021 ESC/EACTS Guidelines for the management of valvular heart disease.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vittal HejjajiDepartment of Cardiovascular Medicine, Saint Luke's Mid America Heart Institute, Kansas City, MO (V.H., A.O.M., J.A.S., S.V.A.).
David J CohenDepartment of Cardiovascular Medicine, University of Missouri-Kansas City (V.H., D.J.C., A.O.M., J.A.S., S.V.A.).
John D CarrollDepartment of Cardiovascular Medicine, University of Colorado Anschutz Medical Campus, Aurora (J.D.C.).
Zhuokai LiDepartment of Cardiovascular Medicine, Duke Clinical Research Institute, Durham, NC (Z.L., P.M., S.V., A.J.N.).
Pratik ManandharDepartment of Cardiovascular Medicine, Duke Clinical Research Institute, Durham, NC (Z.L., P.M., S.V., A.J.N.).
Sreekanth VemulapalliDepartment of Cardiovascular Medicine, Duke Clinical Research Institute, Durham, NC (Z.L., P.M., S.V., A.J.N.).
Adam J NelsonDepartment of Cardiovascular Medicine, Duke Clinical Research Institute, Durham, NC (Z.L., P.M., S.V., A.J.N.).
Ali O MalikDepartment of Cardiovascular Medicine, Saint Luke's Mid America Heart Institute, Kansas City, MO (V.H., A.O.M., J.A.S., S.V.A.).
Michael J MackDepartment of Cardiovascular Medicine, Baylor Scott and White Health, Plano, TX (M.J.M.).
John A SpertusDepartment of Cardiovascular Medicine, Saint Luke's Mid America Heart Institute, Kansas City, MO (V.H., A.O.M., J.A.S., S.V.A.).
Suzanne V ArnoldDepartment of Cardiovascular Medicine, Saint Luke's Mid America Heart Institute, Kansas City, MO (V.H., A.O.M., J.A.S., S.V.A.).

Funding

CARDIOVASCULAR OUTCOMES RESEARCH TRAINING PROGRAMT32HL110837 · NHLBI · UNIVERSITY OF MISSOURI KANSAS CITY · PI JOHN A SPERTUS · 2012 to 2026
$5.0M
NHLBI NIH HHS T32 HL110837
6 · The paper itself

Abstract

backgroundHealth status assessment is essential for documenting the benefit of transcatheter aortic valve replacement (TAVR) or transcatheter mitral valve repair on patients' symptoms, function, and quality of life. Health status can also be a powerful marker for subsequent clinical outcomes, but its prognostic importance around the time of both TAVR and transcatheter mitral valve repair has not been fully defined.

methodsAmong 73 699 patients who underwent transfemoral TAVR or transcatheter mitral valve repair between 2011 and 2018 (mean age, 81.9±7.0 years, 53% men, 92% TAVR), we constructed sequential models examining the association of health status (as assessed with the Kansas City Cardiomyopathy Questionnaire-Overall Summary Score; KCCQ-OS) at baseline, 30 days, change from baseline to 30 days, and combinations of these assessments with death and heart failure (HF) hospitalization from 30 days to 1 year.

resultsAlthough higher baseline KCCQ-OS and 30-day KCCQ-OS scores were each associated with lower risk of death and HF hospitalization (in individual models and in a model including both measures), the 30-day KCCQ-OS was most predictive (death: hazard ratio, 0.89 per 5-point increase [95% CI, 0.89-0.90]; HF hospitalization: hazard ratio, 0.91 [95% CI, 0.90-0.91]). The 30-day KCCQ-OS also was most predictive when included in a separate model with change in KCCQ from baseline to 30 days. Similar findings were noted for the outcomes of death and of HF hospitalization, unadjusted and adjusted for patient factors. All interaction terms between procedure type and KCCQ were not significant, suggesting that health status provided similar prognostic information in both procedures.

conclusionsThe patient's assessment of their health status immediately before and 30 days after TAVR and transcatheter mitral valve repair is associated with subsequent risk of death and HF hospitalization, with the 30-day assessment being most strongly associated with outcomes. Our findings support the routine use of KCCQ data as a prognostic tool.

Indexed as

CardiologyHealth StatusSurgeonsTranscatheter Aortic Valve ReplacementAgedAged, 80 and overAortic Valve StenosisFemaleHumansMalePatient Reported Outcome MeasuresQuality of LifeRegistriesRisk FactorsTreatment OutcomeUnited Statesdeathhealth statusheart failurehospitalizationtranscatheter aortic valve replacement

Identifiers

PMID33596663
PMCPMC7982132

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.