Evidence map›Paper›PMID 33596485›Full record

ArticleDiagnostic microbiology and infectious disease2021

Available COVID-19 serial seroconversion panel for validation of SARS-CoV-2 antibody assays.

Francisco Belda, Monica Lopez-Martinez, Nerea Torres, Robin Cherenzia, Michael Crowley

Open access · hybridAbstract read
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Francisco BeldaResearch and Development, Bio Supplies Division, Grifols, Barcelona, Spain. Electronic address: paco.belda@grifols.com.
Monica Lopez-MartinezR&D Department, Progenika Biopharma, A Grifols Company, Derio, Spain.
Nerea TorresR&D Department, Progenika Biopharma, A Grifols Company, Derio, Spain.
Robin CherenziaAccess Biologicals, Vista, CA, USA.
Michael CrowleyAccess Biologicals, Vista, CA, USA.
Grifols (Spain) · ESAccess to Wholistic and Productive Living Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seroconversion panels are an important tool for investigating antibody responses and developing serological assays. A seroconversion panel was generated from a single SARS-CoV-2 positive plasma donor over 87 days. This seroconversion panel was tested against 6 SARS-CoV-2 antibody tests (IgG, IgM, and total Ig). All test kits utilized recombinant antigens that are specific to SARS-CoV-2. The seroconversion panel showed IgG responses for SARS-CoV-2 after day 50. IgM levels peaked on day 50 (prior to IgG) and declined in subsequent samples. This seroconversion panel is a useful tool for validation of SARS-CoV-2 antibody assays.

Indexed as

SeroconversionAntibodies, ViralConvalescenceCOVID-19COVID-19 Serological TestingEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin GImmunoglobulin MReproducibility of ResultsSARS-CoV-2Antibodies, ViralImmunoglobulin GImmunoglobulin MCOVID-19ImmunoglobulinsSARS-CoV-2Seroconversion panel

Identifiers

PMID33596485
PMCPMC7990520
OpenAlexW3129123581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.