Evidence map›Paper›PMID 33596331›Full record

ArticleAnnals of clinical and translational neurology2021

Deep brain stimulation effects on verbal fluency dissociated by target and active contact location.

Kevin D John, Scott A Wylie, Benoit M Dawant, William J Rodriguez, Fenna T Phibbs, Elise B Bradley, Joseph S Neimat, Nelleke C van Wouwe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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  13. Effects of deep brain stimulation target on the activation and suppression of action impulses.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kevin D JohnDepartment of Neurological Surgery, University of Louisville, Louisville, KY, USA.ORCID 0000-0002-2299-0434
Scott A WylieDepartment of Neurological Surgery, University of Louisville, Louisville, KY, USA.
Benoit M DawantDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA.
William J RodriguezDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA.
Fenna T PhibbsDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Elise B BradleyDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Joseph S NeimatDepartment of Neurological Surgery, University of Louisville, Louisville, KY, USA.
Nelleke C van WouweDepartment of Neurological Surgery, University of Louisville, Louisville, KY, USA.ORCID 0000-0002-7839-0470
University of Louisville · USVanderbilt University · USVanderbilt University Medical Center · US

Funding

Computer-Assited Functional NeurosurgeryR01NS095291 · NINDS · VANDERBILT UNIVERSITY · PI DAWANT, BENOIT M., DHAESE, PIERRE F. · 2015 to 2018
$2.4M
Modulating Inhibitory Action Control Systems With Subthalamic Nucleus StimulationR01NS100996 · NINDS · UNIVERSITY OF LOUISVILLE · PI NEIMAT, JOSEPH S, VAN WOUWE, NELLEKE C. · 2018 to 2022
$1.7M
NINDS NIH HHS R01 NS095291NINDS NIH HHS R01 NS100996NINDS NIH HHS RO1NS095291
6 · The paper itself

Abstract

objectiveDeep brain stimulation (DBS) improves motor symptoms in Parkinson's disease (PD), but it can also disrupt verbal fluency with significant costs to quality of life. The current study investigated how variability of bilateral active electrode coordinates along the superior/inferior, anterior/posterior, and lateral/medial axes in the subthalamic nucleus (STN) or the globus pallidus interna (GPi) contribute to changes in verbal fluency. We predicted that electrode location in the left hemisphere would be linked to changes in fluency, especially in the STN.

methodsForty PD participants treated with bilateral DBS targeting STN (n = 23) or GPi (n = 17) completed verbal fluency testing in their optimally treated state before and after DBS therapy. Normalized atlas coordinates from left and right active electrode positions along superior/inferior, anterior/posterior, and lateral/medial axes were used to predict changes in fluency postoperatively, separately for patients with STN and GPi targets.

resultsConsistent with prior studies, fluency significantly declined pre- to postsurgery (in both DBS targets). In STN-DBS patients, electrode position along the inferior to superior axis in the left STN was a significant predictor of fluency changes; relatively more superior left active electrode was associated with the largest fluency declines in STN. Electrode coordinates in right STN or GPi (left or right) did not predict fluency changes.

interpretationWe discuss these findings in light of putative mechanisms and potential clinical impact.

Indexed as

Deep Brain StimulationGlobus PallidusImplantable NeurostimulatorsPostoperative ComplicationsSubthalamic NucleusAgedCognitive DysfunctionFemaleFunctional LateralityHumansMaleMiddle AgedNeuropsychological TestsParkinson Disease

Identifiers

PMID33596331
PMCPMC7951101
OpenAlexW3133140036

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.