Evidence map›Paper›PMID 33596273›Full record

SynthesisPloS one2021

Interventions to reduce social isolation and loneliness during COVID-19 physical distancing measures: A rapid systematic review.

Christopher Y K Williams, Adam T Townson, Milan Kapur, Alice F Ferreira, Rebecca Nunn, Julieta Galante, Veronica Phillips, Sarah Gentry, Juliet A Usher-Smith

Registry-linked trialOpen access · goldAbstract readSystematic Review
In one paragraph

Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05764902 (Interventions to Reduce Loneliness in Elderly Patients in the Cardiac ICU), which is not on this map. Cited by 107 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 4 pooled it
34.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05764902 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Interventions to Reduce Loneliness in Elderly Patients in the Cardiac ICU (CICU): A Randomized Control Trial

TypeinterventionalSponsorPoriya Medical CenterRan2023 to 2023Enrolled60ConditionsLonelinessArmsPatient-tailored intervention
3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 4 syntheses or guidelines pooled it, 254 citations in OpenAlex.

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  15. Social Isolation, Loneliness, and Cognitive Health.Clinics in geriatric medicine · 2025
    Review
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Christopher Y K WilliamsUniversity of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.ORCID 0000-0001-8867-1623
Adam T TownsonUniversity of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.ORCID 0000-0001-8800-7896
Milan KapurUniversity of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
Alice F FerreiraUniversity of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.ORCID 0000-0002-1596-043X
Rebecca NunnUniversity of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
Julieta GalanteDepartment of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
Veronica PhillipsMedical Library, University of Cambridge, Cambridge, United Kingdom.
Sarah GentryNorwich Medical School, University of East Anglia, Norwich, United Kingdom.
Juliet A Usher-SmithThe Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.ORCID 0000-0002-8501-2531
University of Cambridge · GBUniversity of East Anglia · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA significant proportion of the worldwide population is at risk of social isolation and loneliness as a result of the COVID-19 pandemic. We aimed to identify effective interventions to reduce social isolation and loneliness that are compatible with COVID-19 shielding and social distancing measures. METHODS AND

findingsIn this rapid systematic review, we searched six electronic databases (Medline, Embase, Web of Science, PsycINFO, Cochrane Database of Systematic Reviews and SCOPUS) from inception to April 2020 for systematic reviews appraising interventions for loneliness and/or social isolation. Primary studies from those reviews were eligible if they included: 1) participants in a non-hospital setting; 2) interventions to reduce social isolation and/or loneliness that would be feasible during COVID-19 shielding measures; 3) a relevant control group; and 4) quantitative measures of social isolation, social support or loneliness. At least two authors independently screened studies, extracted data, and assessed risk of bias using the Downs and Black checklist. Study registration: PROSPERO CRD42020178654. We identified 45 RCTs and 13 non-randomised controlled trials; none were conducted during the COVID-19 pandemic. The nature, type, and potential effectiveness of interventions varied greatly. Effective interventions for loneliness include psychological therapies such as mindfulness, lessons on friendship, robotic pets, and social facilitation software. Few interventions improved social isolation. Overall, 37 of 58 studies were of "Fair" quality, as measured by the Downs & Black checklist. The main study limitations identified were the inclusion of studies of variable quality; the applicability of our findings to the entire population; and the current poor understanding of the types of loneliness and isolation experienced by different groups affected by the COVID-19 pandemic.

conclusionsMany effective interventions involved cognitive or educational components, or facilitated communication between peers. These interventions may require minor modifications to align with COVID-19 shielding/social distancing measures. Future high-quality randomised controlled trials conducted under shielding/social distancing constraints are urgently needed.

Indexed as

COVID-19Data ManagementFemaleHumansLonelinessMaleMental HealthPandemicsPhysical DistancingQuarantineSARS-CoV-2Social IsolationSocial Support

Identifiers

PMID33596273
PMCPMC7888614
OpenAlexW3130872383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.