SynthesisPloS one2021
Interventions to reduce social isolation and loneliness during COVID-19 physical distancing measures: A rapid systematic review.
Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05764902 (Interventions to Reduce Loneliness in Elderly Patients in the Cardiac ICU), which is not on this map. Cited by 107 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interventions to Reduce Loneliness in Elderly Patients in the Cardiac ICU (CICU): A Randomized Control Trial
Who cites it
107 citing papers in PubMed, 4 syntheses or guidelines pooled it, 254 citations in OpenAlex.
- Systematic Reviews of Psychosocial Interventions for Loneliness Among Older Adults in Community and Residential Care Settings: An Umbrella Review.Journal of advanced nursing · 2026Pooled it
- Interventions against loneliness and social isolation in older adults- a systematic review.BMC public health · 2026Pooled it
- Social Isolation and Loneliness in People Living With Chronic Kidney Disease and Kidney Failure: A Mixed Method Systematic Review.Journal of renal care · 2026Pooled it
- Tackling social disconnection: an umbrella review of RCT-based interventions targeting social isolation and loneliness.BMC public health · 2024Pooled it
- Trial
- An experimental COVID-19 messaging study in a representative sample of the Scottish population: Increasing physical distancing intentions through self-efficacy.British journal of health psychology · 2023Trial
- Effects of a Multi-Professional Intervention on Mental Health of Middle-Aged Overweight Survivors of COVID-19: A Clinical Trial.International journal of environmental research and public health · 2023Trial
- Effectiveness of a Video-Based Intervention on Reducing Perceptions of Fear, Loneliness, and Public Stigma Related to COVID-19: A Randomized Controlled Trial.International journal of public health · 2021Trial
- Evaluation of a Student-Older Adult Telephone Befriending Program to Reduce Social Isolation During the COVID-19 Pandemic.Canadian geriatrics journal : CGJ · 2026Article
- Mapping loneliness prevention and alleviation interventions: a comparative survey of Basel, Bern, Zurich, and Dublin.Frontiers in public health · 2026Article
- The Impact of Psychosocial Interventions on Older Adults in the Community Experiencing Social Isolation: An Integrative Review.International journal of mental health nursing · 2025Review
- Observational
- Loneliness in the college student population: Prevalence and associations with substance use outcomes.Journal of American college health : J of ACH · 2025Article
- [Development and effects of a customized integrated health management program for older adults living alone: A nonequivalent control-group pre-posttest design].Journal of Korean gerontological nursing · 2025Article
- Social Isolation, Loneliness, and Cognitive Health.Clinics in geriatric medicine · 2025Review
- Incidence and Characteristics of Alcohol-Based Hand Sanitizer Ingestion in Florida before and during the Coronavirus Pandemic.The western journal of emergency medicine · 2025Article
- Guidelines for evaluating and reporting social isolation and loneliness interventions.Journal of health psychology · 2025Article
- Harnessing the transformative potential of gamified virtual reality sports to enhance perceived life expectancy in older men at risk of suicide.Frontiers in public health · 2025Article
- Associations between mental health and lifestyle changes during the COVID-19 pandemic in a general Japanese population: NIPPON DATA2010.Environmental health and preventive medicine · 2025Article
- Risk factors for, metrics of, and consequences of access to veterinary care for companion animals: A scoping review.PloS one · 2025Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA significant proportion of the worldwide population is at risk of social isolation and loneliness as a result of the COVID-19 pandemic. We aimed to identify effective interventions to reduce social isolation and loneliness that are compatible with COVID-19 shielding and social distancing measures. METHODS AND
findingsIn this rapid systematic review, we searched six electronic databases (Medline, Embase, Web of Science, PsycINFO, Cochrane Database of Systematic Reviews and SCOPUS) from inception to April 2020 for systematic reviews appraising interventions for loneliness and/or social isolation. Primary studies from those reviews were eligible if they included: 1) participants in a non-hospital setting; 2) interventions to reduce social isolation and/or loneliness that would be feasible during COVID-19 shielding measures; 3) a relevant control group; and 4) quantitative measures of social isolation, social support or loneliness. At least two authors independently screened studies, extracted data, and assessed risk of bias using the Downs and Black checklist. Study registration: PROSPERO CRD42020178654. We identified 45 RCTs and 13 non-randomised controlled trials; none were conducted during the COVID-19 pandemic. The nature, type, and potential effectiveness of interventions varied greatly. Effective interventions for loneliness include psychological therapies such as mindfulness, lessons on friendship, robotic pets, and social facilitation software. Few interventions improved social isolation. Overall, 37 of 58 studies were of "Fair" quality, as measured by the Downs & Black checklist. The main study limitations identified were the inclusion of studies of variable quality; the applicability of our findings to the entire population; and the current poor understanding of the types of loneliness and isolation experienced by different groups affected by the COVID-19 pandemic.
conclusionsMany effective interventions involved cognitive or educational components, or facilitated communication between peers. These interventions may require minor modifications to align with COVID-19 shielding/social distancing measures. Future high-quality randomised controlled trials conducted under shielding/social distancing constraints are urgently needed.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.