Evidence map›Paper›PMID 33596183›Full record

ArticleAging2021

Sex and age-related differences in cerebral blood flow investigated using pseudo-continuous arterial spin labeling magnetic resonance imaging.

Joseph S R Alisch, Nikkita Khattar, Richard W Kim, Luis E Cortina, Abinand C Rejimon, Wenshu Qian, Luigi Ferrucci, Susan M Resnick, Richard G Spencer, Mustapha Bouhrara

Abstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Trial
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  16. The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. Sex differences in gray matter, white matter, and regional brain perfusion in young, healthy adults.American journal of physiology. Heart and circulatory physiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joseph S R AlischLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 20892, USA.
Nikkita KhattarLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 20892, USA.
Richard W KimLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 20892, USA.
Luis E CortinaLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 20892, USA.
Abinand C RejimonLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 20892, USA.
Wenshu QianLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 20892, USA.
Luigi FerrucciLaboratory Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 20892, USA.
Susan M ResnickLaboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD 20892, USA.
Richard G SpencerLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 20892, USA.
Mustapha BouhraraLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 20892, USA.

Funding

Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2020 to 2026
$29.3M
NIA NIH HHS P30 AG066507
6 · The paper itself

Abstract

Adequate cerebral blood flow (CBF) is essential to a healthy central nervous system (CNS). Previous work suggests that CBF differs between men and women, and declines with age and certain pathologies, but a highly controlled systematic study across a wide age range, and incorporating white matter (WM) regions, has not been undertaken. Here, we investigate age- and sex-related differences in CBF in gray matter (GM) and WM regions in a cohort (

Indexed as

AgingMagnetic Resonance ImagingAdultAgedAged, 80 and overAge FactorsCerebrovascular CirculationFemaleGray MatterHealthy VolunteersHumansMaleMiddle AgedSex FactorsWhite Matteragingarterial spin labelingcerebral blood flowMRI

Identifiers

PMID33596183
PMCPMC7950235

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.