Evidence map›Paper›PMID 33596152›Full record

ArticleThe European journal of contraception & reproductive health care : the official journal of the European Society of Contraception2021

An exploratory study on the association of lifestyle factors with serum etonogestrel concentrations among contraceptive implant users.

Aaron Lazorwitz, Jeanelle Sheeder, Stephanie Teal

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03092037 (Pharmacogenomics of Contraception), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03092037 completednot on this map

Pharmacogenomics of Contraception: Genetic Variants and Etonogestrel Pharmacokinetics

TypeobservationalSponsorUniversity of Colorado, DenverRan2017 to 2022Enrolled900ConditionsContraceptionArmsBlood draw
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Observational
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Aaron LazorwitzDepartment of Obstetrics and Gynecology, Division of Family Planning, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID https://orcid.org/0000-0003-0208-8432
Jeanelle SheederDepartment of Obstetrics and Gynecology, Division of Family Planning, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Stephanie TealDepartment of Obstetrics and Gynecology, Division of Family Planning, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
University of Colorado Anschutz Medical Campus · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
COLORADO WRHR CAREER DEVELOPMENT CENTERK12HD001271 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Saketh R Guntupalli · 1999 to 2026
$8.9M
NCATS NIH HHS UL1 TR001082NCATS NIH HHS UL1 TR002535NICHD NIH HHS K12 HD001271
6 · The paper itself

Abstract

purposeTo explore how diet and exercise habits associate with serum etonogestrel concentrations among contraceptive implant users. MATERIALS AND

methodsWe conducted a secondary analysis of healthy, reproductive-age women using etonogestrel implants. This study was registered on ClinicalTrials.gov, NCT03092037. We assessed diet and exercise habits with two validated surveys: Healthy Eating Vital Signs and the Stanford Brief Activity Survey. Participants previously had their serum etonogestrel concentrations measured using a validated liquid-chromatography mass-spectrometry assay. We then used linear modelling to test for associations between survey responses and serum etonogestrel concentrations.

resultsAmong 129 participants, diet and exercise habits had no significant associations with serum etonogestrel concentrations (

conclusionThis exploratory study found no significant effect of diet or exercise habits on steady-state pharmacokinetics among contraceptive implant users. CLINICAL

trial registrationClinicaltrials.gov: NCT03092037.

Indexed as

Drug ImplantsLife StyleContraceptive Agents, FemaleContraceptive Agents, HormonalDesogestrelFemaleHumansContraceptive Agents, FemaleContraceptive Agents, HormonalDesogestrelDrug Implantsetonogestrelcontraceptive implantdietetonogestrelexerciseLifestylepharmacokinetics

Identifiers

PMID33596152
PMCPMC8496990
OpenAlexW3129622632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.