Evidence map›Paper›PMID 33596114›Full record

ArticleJCO oncology practice2021

Measuring Financial Distress and Quality of Life Over Time in Patients With Gynecologic Cancer-Making the Case to Screen Early in the Treatment Course.

Margaret I Liang, Sarah S Summerlin, Christina T Blanchard, Teresa K L Boitano, Warner K Huh, Smita Bhatia, Maria Pisu

Registry-linked trialAbstract read
In one paragraph

Article in JCO oncology practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03422198 (Short Course Adjuvant Vaginal Cuff Brachytherapy), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03422198 phase3recruitingnot on this map

Short Course Adjuvant Vaginal Cuff Brachytherapy (VCB) in Early Endometrial Cancer Compared to Standard of Care (SAVE)

TypeinterventionalSponsorUniversity of UtahRan2018 to 2029Enrolled188ConditionsEndometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Serous Adenocarcinoma, Stage I Uterine Corpus CancerArmsVaginal Cuff Brachytherapy, Short course vaginal cuff brachytherapy
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Rural patients' experiences with diagnosis and treatment of endometrial cancer.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025
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  18. Patient-reported benefit from proposed interventions to reduce financial toxicity during cancer treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Margaret I LiangDivision of Gynecologic Oncology, Department of Obstetrics & Gynecology, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0001-9229-5181
Sarah S SummerlinSchool of Medicine, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-1571-6381
Christina T BlanchardCenter for Women's Reproductive Health, Department of Obstetrics & Gynecology, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-1244-1271
Teresa K L BoitanoDepartment of Obstetrics & Gynecology, University of Alabama at Birmingham, Birmingham, AL.
Warner K HuhDivision of Gynecologic Oncology, Department of Obstetrics & Gynecology, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0003-2881-9846
Smita BhatiaDivision of Pediatric Hematology & Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0002-7755-5683
Maria PisuDivision of Preventive Medicine, Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, AL.ORCID 0000-0001-9329-3268

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Treatment of HIV- and HIV+ Patients with HPV16+ CIN2/3 Using pNGLV4a-hCRTE6E7L2 DNA vaccine administered intramuscularly via electroporationP50CA098252 · NCI · JOHNS HOPKINS UNIVERSITY · PI Richard Bruce Roden · 2003 to 2026
$53.5M
OB/GYN FACULTY RESEARCH CAREER DEVELOPMENT PROGRAMK12HD001258 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JENKINS, TODD R · 1999 to 2019
$5.6M
NCI NIH HHS P30 CA013148NCI NIH HHS P50 CA098252NICHD NIH HHS K12 HD001258
6 · The paper itself

Abstract

purposeOur objective was to measure the trajectory of financial distress and to determine its relationship with quality of life (QOL) among patients with cancer. MATERIALS AND

methodsWe conducted a longitudinal survey of patients with gynecologic cancer starting a new line of systemic therapy at baseline, 3 months, and 6 months. Financial distress was measured using a Comprehensive Score for Financial Toxicity (COST) < 26, and QOL was measured using Functional Assessment of Cancer Therapy-General (FACT-G) with lower scores indicating worse responses. One-way repeated analysis of variances, generalized estimating equation models, and correlation coefficients were used to evaluate financial distress and QOL over time.

resultsThere were 90 of 121 (74%) baseline participants with a 6-month follow-up. The average age was 60 years, 29% were African-American, 57% had an annual income < $40,000 in US dollars, and 6% were uninsured. At baseline, 54% of patients screened positive for financial distress, which was unchanged at 3 months (50%,

conclusionUpfront screening with COST identified 90% of patients who experienced financial distress, and COST did not change significantly over time. More severe financial distress was moderately correlated with worse QOL, and its presence was associated with a clinically meaningful 16-point decrease in QOL.

Indexed as

Genital Neoplasms, FemaleQuality of LifeFemaleHumansLongitudinal StudiesMiddle Aged

Identifiers

PMID33596114
PMCPMC8791820

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.