ArticleMolecular biology of the cell2021
Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2.
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Article in Molecular biology of the cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- Article
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- Gut microbiota dysbiosis in sepsis and sepsis-associated organ injury: mechanisms, gut-organ axes, and therapeutic strategies.Frontiers in microbiology · 2026Review
- Transcriptome-Based Analysis of Core Hub Genes Related to Cell Adhesion in Vero Cells.BioMed research international · 2026Article
- Dietary Flavonoids as Cross-System Modulators of Hypertension and Intestinal Permeability.Molecules (Basel, Switzerland) · 2025Review
- Relevance of porcine intestinal organoids as a surrogate for animal experimentation: application to the investigation of host-virus interactions during porcine coronavirus infection.Veterinary research · 2025Article
- Meeting report - Alpine desmosome disease meeting 2024: advances and emerging topics in desmosomes and related diseases.Journal of cell science · 2025Article
- Gut-bone axis perturbation: Mechanisms and interventions via gut microbiota as a primary driver of osteoporosis.Journal of orthopaedic translation · 2025Review
- Duodenal Organoids From Metabolic Dysfunction-Associated Steatohepatitis Patients Exhibit Absorptive and Barrier Alterations.Gastro hep advances · 2025Article
- STARD7 maintains intestinal epithelial mitochondria architecture, barrier integrity, and protection from colitis.JCI insight · 2024Article
- The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells.Developmental cell · 2024Article
- Microbial Signatures in COVID-19: Distinguishing Mild and Severe Disease via Gut Microbiota.Biomedicines · 2024Article
- Review
- Effects of medical plants on alleviating the effects of heat stress on chickens.Poultry science · 2024Review
- Review
- Experimentally validated oxidative stress -associated prognostic signatures describe the immune landscape and predict the drug response and prognosis of SKCM.Frontiers in immunology · 2024Article
- Claudin-23 reshapes epithelial tight junction architecture to regulate barrier function.Nature communications · 2023Article
- Protocatechuic Acid Alleviates Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Mice via the Regulation of Intestinal Flora and Ferroptosis.Molecules (Basel, Switzerland) · 2023Article
- Mechanisms of gastrointestinal barrier dysfunction in COVID-19 patients.World journal of gastroenterology · 2023Review
- Microbiota of the gastrointestinal tract: Friend or foe?World journal of gastroenterology · 2023Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Arturo Raya-SandinoDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109.
Anny-Claude LuissintDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109.
Dennis H M KustersDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109.
Vani NarayananDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284.
Sven FlemmingDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109.
Vicky Garcia-HernandezDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109.
Lisa M GodselDepartments of Pathology and Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Kathleen J GreenDepartments of Pathology and Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Susan J HagenDepartment of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02115.
Daniel E ConwayDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284.
Charles A ParkosDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109.
Asma NusratDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109.
University of Michigan · USNorthwestern University · USVirginia Commonwealth University · USBeth Israel Deaconess Medical Center · US
Funding
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4MUniversity of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1986 to 2021
$22.5MMOLECULAR GENETICS OF PEMPHIGUS FOLIACEUS ANTIGENR01AR041836 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1993 to 2026
$11.8MRegulation of intestinal epithelial barrier function by intercellular junction proteins in health and diseaseR01DK059888 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ASMA NUSRAT · 2001 to 2026
$10.5MCARCINOGENESIS TRAINING PROGRAMT32CA009560 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1986 to 2026
$8.4MIntestinal Mucosal Wound Resealing in IBDR01DK055679 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ASMA NUSRAT · 2004 to 2026
$8.1MIntestinal Inflammation: Signaling proteins and the rate of PMN transmigrationR01DK079392 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARKOS, CHARLES A · 2007 to 2025
$7.2MDESMOPLAKIN FUNCTION IN EPIDERMISR01AR043380 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1996 to 2026
$7.0MNeutrophil Interactions with Intestinal Epithelial CellsR01DK072564 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARKOS, CHARLES A · 2005 to 2020
$6.5MStructure-Function Studies on Intestinal Epithelial JAMR01DK061379 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARKOS, CHARLES A · 2002 to 2021
$6.3MFormyl peptide receptors as mediators of intestinal mucosal homeostasisR01DK089763 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEISH, ANDREW S, NUSRAT, ASMA · 2011 to 2020
$4.7MDesmoplakin Assembly and Function in EpidermisR37AR043380 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GREEN, KATHLEEN JANEE · 2011 to 2020
$4.6MNCI NIH HHS T32 CA009560NIAMS NIH HHS R01 AR041836NIAMS NIH HHS R01 AR043380NIAMS NIH HHS R03 AR068096NIAMS NIH HHS R37 AR043380NIDDK NIH HHS P30 DK034854NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK055679NIDDK NIH HHS R01 DK059888NIDDK NIH HHS R01 DK061379NIDDK NIH HHS R01 DK072564NIDDK NIH HHS R01 DK079392NIDDK NIH HHS R01 DK089763NIDDK NIH HHS R29 DK055679NIDDK NIH HHS R56 DK089763NIGMS NIH HHS R35 GM119617
Abstract
The role of desmosomal cadherin desmocollin-2 (Dsc2) in regulating barrier function in intestinal epithelial cells (IECs) is not well understood. Here, we report the consequences of silencing Dsc2 on IEC barrier function in vivo using mice with inducible intestinal-epithelial-specific
Indexed as
AnimalsCadherinsCell AdhesionCell LineCell MembraneDesmocollinsDesmoglein 2Desmosomal CadherinsDesmosomesHumansIntercellular JunctionsIntestinal MucosaMaleMiceMice, KnockoutCadherinsDesmocollinsDesmoglein 2Desmosomal CadherinsDSC2 protein, humanDsc2 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.