ReviewActa physiologica (Oxford, England)2021
Nicotine and vascular dysfunction.
Review in Acta physiologica (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Determinants of Cardiovascular Disease Risk Among LGBTQ+ Populations: A Systematic Review of Empirical Evidence.Nursing open · 2026Pooled it
- Pharmacological Interventions for Electronic Cigarette Cessation: A Systematic Review and Meta-analyses.Journal of addiction medicinePooled it
- Risk Modulation by Electronic Cigarette Consumption in Cardiovascular Disease and Its Relevance in Cardiac Surgery-A Narrative Review.Journal of cardiovascular development and disease · 2026Review
- Exploring the Discourse Around Zyn Nicotine Pouches on Instagram and TikTok: Content Analysis.JMIR infodemiology · 2026Article
- E-cigarette Aerosol Containing Nicotine Increases Aortic Stiffness in Young Mice.Cardiovascular toxicology · 2026Article
- Expression Profiles of α1nAChR, ERK1/2, c-FOS and Matrix Metalloproteinases Among Male Smokers with Acute Coronary Syndrome.International journal of molecular sciences · 2026Article
- Association of Smoking Status and Urinary Cotinine Levels With Lipoprotein(a) in Korean Adults.Journal of lipid and atherosclerosis · 2026Article
- Lifestyle factors and cardiometabolic risk.Chinese medical journal · 2026Review
- A Parsimonious Four-Variable Nomogram for Predicting Lower-Extremity Amputation in Patients with Type 2 Diabetes and Diabetic Foot Ulcers: Development and Internal Validation Using Dual-Method Stability-Based Variable Selection.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Nicotinic acetylcholine receptors in pain modulation.Frontiers in pharmacology · 2026Review
- Occupational tobacco exposure and multisystem morbidity among beedi rollers: biomarker-validated evidence from a multi-state study in India.Frontiers in public health · 2026Observational
- A novel redox signalling axis mediates nicotine-induced podocyte injury.Frontiers in pharmacology · 2026Article
- Warning and informative messages on e-cigarette package leaflets: A Belgian policy case study for public health policymakers.Tobacco prevention & cessation · 2026Article
- The effect of smoking on the radiological and functional outcomes of anterior cervical discectomy and fusion with anchored standalone cages.Journal of spine surgery (Hong Kong) · 2025Article
- The correlation between smoking and preoperative deep venous thrombosis after hip fracture in geriatric patients: a propensity score-matched study.Journal of orthopaedic surgery and research · 2025Article
- Uncovering a novel role of nAChRs in oxidative stress-mediated vascular dysfunction in COPD.Redox biology · 2025Article
- Role of SLC16A10 in Psoriasis Through the Regulation of Arachidonic Acid Metabolism in Keratinocytes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Non-Tobacco Nicotine Use and Complications in Free Flap Repair in Head and Neck Cancer.The Laryngoscope · 2025Article
- The impact of electronic cigarettes on pregnancy and childhood health outcomes: the ECHO study-a protocol for a multicentre, prospective, observational, cohort.Archives of gynecology and obstetrics · 2025Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cigarette smoking is the single most important risk factor for the development of cardiovascular diseases (CVDs). However, the role of nicotine, the addictive component of all tobacco products, in the development of CVD is incompletely understood. Although increased public awareness of the harms of cigarette smoking has successfully led to a decline in its prevalence, the use of electronic cigarettes (e-cig) or electronic nicotine delivery system has increased dramatically in recent years because of the perception that these products are safe. This review summarizes our current knowledge of the expression and function of the nicotinic acetylcholine receptors in the cardiovascular system and the impact of nicotine exposure on cardiovascular health, with a focus on nicotine-induced vascular dysfunction. Nicotine alters vasoreactivity through endothelium-dependent and/or endothelium-independent mechanisms, leading to clinical manifestations in both cigarette smokers and e-cig users. In addition, nicotine induces vascular remodelling through its effects on proliferation, migration and matrix production of both vascular endothelial and vascular smooth muscle cells. The purpose of this review is to identify critical knowledge gaps regarding the effects of nicotine on the vasculature and to stimulate continued nicotine research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.