ArticleJournal of computational neuroscience2021
Predictive coding models for pain perception.
Article in Journal of computational neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed.
- Chronic pain and oscillatory neuroplasticity: Review on impaired compensatory network responses in resting-state electroencephalography.Brain network disorders · 2026Article
- Motor Training Integrating Cognitive-Behavioral Strategies and Narrative Grammar in Children with Autism Using the Global Integration Method (MIG): A Randomized Clinical Trial.Healthcare (Basel, Switzerland) · 2026Article
- Exposure to false cardiac feedback alters pain perception and anticipatory cardiac frequency.eLife · 2026Article
- Review
- Temporal Interference Stimulation of the Motor Cortex Produces Frequency-Dependent Analgesia.bioRxiv : the preprint server for biology · 2026Article
- Beyond device parameters: psychological predictors of spinal cord stimulation success and their neurobiological mechanisms-a narrative review.Frontiers in psychology · 2026Review
- Effectiveness of the Global Integration Method (Método de Integração Global - MIG) for improving motor and functional outcomes in children with autism spectrum disorder: a randomised controlled trial protocol.Frontiers in pediatrics · 2026Article
- Investigating the Influence of Experimentally Induced Secondary Hyperalgesia on Pain Prediction Error Encoding in Healthy Individuals: A Novel Virtual Reality Protocol.European journal of pain (London, England) · 2025Article
- Exploring the role of negative expectations and emotions in primary dysmenorrhea: insights from a case-control study.BMC women's health · 2025Article
- Expectation generation and its effect on subsequent pain and visual perception.PLoS computational biology · 2025Article
- Thermosensory predictive coding underpins an illusion of pain.Science advances · 2025Article
- Reimagining pain as an allostatic imperative: perspectives from contemplative traditions.Neuroscience of consciousness · 2025Article
- Development, Insults and Predisposing Factors of the Brain's Predictive Coding System to Chronic Perceptual Disorders-A Life-Course Examination.Brain sciences · 2024Article
- Spatial summation of pain is associated with pain expectations: Results from a home-based paradigm.PloS one · 2024Article
- The Effect of Perioperative Auditory Stimulation with Music on Procedural Pain: A Narrative Review.Current pain and headache reports · 2023Review
- Post-injury pain and behaviour: a control theory perspective.Nature reviews. Neuroscience · 2023Review
- Article
- Review
- Hierarchical predictive coding in distributed pain circuits.Frontiers in neural circuits · 2023Review
- Measuring pain and nociception: Through the glasses of a computational scientist. Transdisciplinary overview of methods.Frontiers in network physiology · 2023Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Pain is a complex, multidimensional experience that involves dynamic interactions between sensory-discriminative and affective-emotional processes. Pain experiences have a high degree of variability depending on their context and prior anticipation. Viewing pain perception as a perceptual inference problem, we propose a predictive coding paradigm to characterize evoked and non-evoked pain. We record the local field potentials (LFPs) from the primary somatosensory cortex (S1) and the anterior cingulate cortex (ACC) of freely behaving rats-two regions known to encode the sensory-discriminative and affective-emotional aspects of pain, respectively. We further use predictive coding to investigate the temporal coordination of oscillatory activity between the S1 and ACC. Specifically, we develop a phenomenological predictive coding model to describe the macroscopic dynamics of bottom-up and top-down activity. Supported by recent experimental data, we also develop a biophysical neural mass model to describe the mesoscopic neural dynamics in the S1 and ACC populations, in both naive and chronic pain-treated animals. Our proposed predictive coding models not only replicate important experimental findings, but also provide new prediction about the impact of the model parameters on the physiological or behavioral read-out-thereby yielding mechanistic insight into the uncertainty of expectation, placebo or nocebo effect, and chronic pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.