Evidence map›Paper›PMID 33595736›Full record

ArticleVirchows Archiv : an international journal of pathology2021

Primary uterine ectomesenchymoma harboring a DICER1 mutation: case report with molecular analysis.

Ben Davidson, Lilach Kleinberg, Ida Marie Børresen, Frøydis Slettevoll, Anne Fangberget, Dunia Hindosh, Ane Gerda Zahl Eriksson, Bodil Bjerkehagen

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ben DavidsonDepartment of Pathology, Oslo University Hospital, Norwegian Radium Hospital, Montebello, N-0310, Oslo, Norway. bend@medisin.uio.no.ORCID http://orcid.org/0000-0003-3332-8427
Lilach KleinbergDepartment of Pathology, Oslo University Hospital, Norwegian Radium Hospital, Montebello, N-0310, Oslo, Norway.
Ida Marie BørresenDepartment of Pathology, Oslo University Hospital, Norwegian Radium Hospital, Montebello, N-0310, Oslo, Norway.
Frøydis SlettevollDepartment of Radiology, Oslo University Hospital, Norwegian Radium Hospital, N-0310, Oslo, Norway.
Anne FangbergetDepartment of Radiology, Oslo University Hospital, Norwegian Radium Hospital, N-0310, Oslo, Norway.
Dunia HindoshDepartment of Radiology, Kalnes Hospital, Kalnesveien 300, 1714, Grålum, Norway.
Ane Gerda Zahl ErikssonDepartment of Gynecologic Oncology, Oslo University Hospital, Norwegian Radium Hospital, N-0310, Oslo, Norway.
Bodil BjerkehagenDepartment of Pathology, Oslo University Hospital, Norwegian Radium Hospital, Montebello, N-0310, Oslo, Norway.
Oslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ectomesenchymoma is an exceedingly rare biphasic malignant tumor characterized by the presence of mesenchymal and neuroectodermal elements. The majority of patients are infants or children. We describe the first case of this entity diagnosed as a primary uterine tumor. A 72-year-old female presented with post-menopausal bleeding. Dilatation and curettage showed irregular mesenchymal proliferation of uncertain nature. In the hysterectomy specimen, a myxoid spindle cell tumor with areas of skeletal muscle and neural differentiation was found in the uterus, with direct invasion of the small intestine, and biphasic differentiation into rhabdomyosarcoma and ganglioneuroblastoma was unequivocally seen in a lymph node metastasis. The morphological findings were validated by immunohistochemistry. Massive parallel sequencing identified TP53, PTEN, and DICER1 mutations in the tumor. This report describes the presence of ectomesenchymoma in an unusual primary organ and in an uncharacteristic age and presents novel data regarding the genetic characteristics of this tumor.

Indexed as

MutationAgedBiomarkers, TumorDEAD-box RNA HelicasesDNA Mutational AnalysisFemaleGanglioneuroblastomaGenetic Predisposition to DiseaseHigh-Throughput Nucleotide SequencingHumansHysterectomyMesenchymomaPhenotypePTEN PhosphohydrolaseRhabdomyosarcomaRibonuclease IIIBiomarkers, TumorDEAD-box RNA HelicasesDICER1 protein, humanPTEN PhosphohydrolasePTEN protein, humanRibonuclease IIITP53 protein, humanTumor Suppressor Protein p53EctomesenchymomaImmunohistochemistryMassive parallel sequencingMetastasisUterus

Identifiers

PMID33595736
PMCPMC8364549
OpenAlexW3131780033

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.