Evidence map›Paper›PMID 33595730›Full record

ArticleClinical and experimental nephrology2021

A cross-sectional study in patients with IgA nephropathy of correlations between clinical data and pathological findings at the time of renal biopsy: a Japanese prospective cohort study.

Chisako Kamano, Akira Shimizu, Kensuke Joh, Akinori Hashiguchi, Satoshi Hisano, Ritsuko Katafuchi, Tetsuya Kawamura, Japan IgA nephropathy prospective cohort Study Group

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Article in Clinical and experimental nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chisako KamanoDepartment of Analytic Human Pathology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.
Akira ShimizuDepartment of Analytic Human Pathology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan. ashimizu@nms.ac.jp.ORCID http://orcid.org/0000-0002-4364-9251
Kensuke JohDepartment of Pathology, The Jikei University School of Medicine, Tokyo, Japan.
Akinori HashiguchiDepartment of Pathology, Keio University School of Medicine, Tokyo, Japan.
Satoshi HisanoDepartment of Pathology, University of Occupational and Environmental Health, Fukuoka, Japan.
Ritsuko KatafuchiKidney Unit, National Hospital Organization Fukuoka-Higashi Medical Center, Fukuoka, Japan.
Tetsuya KawamuraDivision of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Japan IgA nephropathy prospective cohort Study Group
Jikei University School of Medicine · JPNippon Medical School · JPUniversity of Occupational and Environmental Health Japan · JP

Funding

AMED JP19ek0109261
6 · The paper itself

Abstract

backgroundThe correlations between clinical data and pathological findings at the time of renal biopsy were investigated in IgA nephropathy patients.

methods771 patients diagnosed with IgA nephropathy by renal biopsy were enrolled. The correlations between clinical variables including eGFR, daily proteinuria, mean arterial pressure (MAP), serum uric acid (UA) values, and pathological parameters were examined. These patients were further divided into three groups: children (< 19 years old), young adults (19-60 years), and elderly patients (> 60 years).

resultsDaily proteinuria was moderately correlated with all pathological parameters (Rs = 0.23-0.49). The mesangial score, the percentage of glomeruli that contained endocapillary hypercellularity, cellular/fibrocellular crescents or tuft necrosis, and segmental glomerulosclerosis (GS) affected daily proteinuria most on multiple linear regression analysis (MLRA). eGFR, MAP, and serum UA levels were mainly correlated with the degree of GS and interstitial lesions. In children, the degree of cellular/fibrocellular crescents or tuft necrosis was correlated with not only daily proteinuria, but also decreased eGFR (Rs = 0.51, - 0.24). Endocapillary hypercellularity was the only independent variable related to daily proteinuria on MLRA.

conclusionIn all age cohorts of IgA nephropathy patients, daily proteinuria was correlated with all histological parameters, including both acute and chronic glomerular lesions, and the mesangial score. Independent variables for daily proteinuria were the meangial score, acute histological lesions, and segmental GS on MLRA, whereas the remaining independent variable in the pediatric group was endocapillary hypercellurality. The clinical pathological correlation at the time of biopsy varied depending on the age group.

Indexed as

AdolescentAdultAgedAged, 80 and overArterial PressureBiopsyChildChild, PreschoolCross-Sectional StudiesFemaleGlomerular Filtration RateGlomerular MesangiumGlomerulonephritis, IGAGlomerulosclerosis, Focal SegmentalHumansJapanUric AcidCorrelation between clinical data and pathological findingsIgA nephropathyJapan IgA nephropathy prospective cohort studyJIGACS

Identifiers

PMID33595730
OpenAlexW3133445291

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.