Evidence map›Paper›PMID 33595711›Full record

ArticlePediatric nephrology (Berlin, Germany)2021

Constipation on abdominal radiograph as potential risk factor for recurrent urinary tract infection development.

Gysella Muniz, Erica Kar, Serter Gumus, Hui Liu, Nader Shaikh

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Gysella MunizChildren's Hospital of Pittsburgh of UPMC, Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, One Children's Hospital Drive, 4401 Penn Ave, Pittsburgh, PA, 15224, USA.ORCID 0000-0003-2476-4008
Erica KarChildren's Hospital of Pittsburgh of UPMC, Division of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Serter GumusChildren's Hospital of Pittsburgh of UPMC, Division of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Hui LiuChildren's Hospital of Pittsburgh of UPMC, Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, One Children's Hospital Drive, 4401 Penn Ave, Pittsburgh, PA, 15224, USA.
Nader ShaikhChildren's Hospital of Pittsburgh of UPMC, Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, One Children's Hospital Drive, 4401 Penn Ave, Pittsburgh, PA, 15224, USA. nader.shaikh@chp.edu.
University of Pittsburgh · US

Funding

Randomized Intervention for Vesicoureteral Reflux (RIVUR)U01DK074059 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CARPENTER, MYRA A. · 2005 to 2012
$11.3M
RIVUR - Randomized Intervention for Children with Vesicoureteral RefluxU01DK074053 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOBERMAN, ALEJANDRO · 2005 to 2012
$4.3M
RIVUR StudyU01DK074062 · NIDDK · WAYNE STATE UNIVERSITY · PI MATTOO, TEJ K · 2005 to 2012
$4.0M
Risk factors for renal scarring in children after urinary tract infectionR01DK078045 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI KEREN, RON · 2008 to 2012
$2.9M
Randomized Intervention for VesicolUreteral Reflux (RIVUR) StudyU01DK074064 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI KEREN, RON · 2005 to 2012
$2.8M
Randomized Intervention for Vesico-Ureteral Reflux (RIVUR) TrialU01DK074082 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WANG, MING-HSIEN · 2005 to 2012
$2.5M
NIDDK NIH HHS R01 DK078045NIDDK NIH HHS U01 DK074053NIDDK NIH HHS U01 DK074059NIDDK NIH HHS U01 DK074062NIDDK NIH HHS U01 DK074064NIDDK NIH HHS U01 DK074082
6 · The paper itself

Abstract

backgroundTo compare clinical history and measurements of fecal load on abdominal radiography (AR) in the prediction of urinary tract infection (UTI) recurrence in children.

methodsWe combined data from two multicenter longitudinal studies in which children less than 6 years of age with a first or second UTI were followed for recurrence of UTI. Two radiologists reviewed the scout abdominal radiographs of initial voiding cystourethrograms obtained at enrollment from children at two participating sites and measured stool visible in various parts of the colon. We examined how well clinical variables (e.g., voiding and bowel history, use of laxatives at enrollment) and measurements of fecal load predicted recurrence of UTI within 12 months of enrollment.

resultsOne hundred and ninety-two children were included. On univariate analyses, age, vesicoureteral reflux (VUR), cecal diameter, rectal diameter, and total stool length on AR were associated with recurrence of UTI. After controlling for age, the odds of recurrent UTI in children with VUR at baseline was 3.85 (95% CI: 1.62, 9.14) higher than in children without VUR. Recurrent UTI was 2.57 (95% CI: 1.01, 6.55) times more likely in children with cecal diameter > 3.10 cm than children with lower cecal diameters; time to first recurrent UTI was shorter in children with elevated cecal diameters (p = 0.0023).

conclusionsCecal diameter on abdominal radiographs predicts UTI recurrence in children with a previous UTI. However, its accuracy is suboptimal to serve as a screening test. Accordingly, its routine use for this indication is not supported. If cecal diameter on an AR ordered for another indication is > 3.10 cm, then management of constipation could be considered.

Indexed as

ConstipationUrinary Tract InfectionsVesico-Ureteral RefluxChildHumansRadiography, AbdominalRetrospective StudiesRisk FactorsAbdominal radiographConstipationUrinary tract infections

Identifiers

PMID33595711
PMCPMC12947162
OpenAlexW3132369155

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.