ReviewThe Journal of international medical research2021
Current concepts in the pathogenesis of cryptoglandular perianal fistula.
Review in The Journal of international medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Early diagnosis of Crohn's disease in patients presenting with a perianal fistula: systematic review and development of a perianal red flags index.Techniques in coloproctology · 2025Pooled it
- Cutting seton for the treatment of cryptoglandular fistula-in-ano: a systematic review and meta-analysis.Techniques in coloproctology · 2023Pooled it
- Multiomics analysis dissects the molecular foundation of perianal fistulas associated with Crohn's disease and of cryptoglandular origin.Journal of Crohn's & colitis · 2026Article
- Not Just a Cyst: A Draining Gluteal Lesion Revealing a Rectocutaneous Fistula in Ulcerative Colitis.ACG case reports journal · 2026Article
- Article
- Concurrent Management of Prostate Cancer and Perianal Fistula: A Case Report, Treatment Considerations, and Review of Literature.Case reports in urology · 2026Article
- Article
- Complete blood counts and their derived inflammatory markers with anal fistulas in male children: A retrospective case-control study.World journal of gastroenterology · 2025Article
- Ligation of the intersphincteric fistula fract (LIFT) in complex anorectal fistulas: retrospective analysis of the outcomes in a tertiary hospital.Updates in surgery · 2025Article
- Rerouting of the tract in the treatment of high anal fistula: a single-center experience.Techniques in coloproctology · 2025Article
- Modified fistulotomy with internal orifice distalization for optimized perianal fistula management: Pressure zone transition.World journal of gastrointestinal surgery · 2025Article
- Understanding the anatomical basis of anorectal fistulas and their surgical management: exploring different types for enhanced precision and safety.Surgery today · 2025Review
- Technical approach in the management of perianal fistula: combining ovine extracellular matrix with endoanal ultrasound to review the surgical outcome.Annals of coloproctology · 2025Article
- The Pouch Corner: Perianal Fistulas and Ileal Pouches: Examining Fistulas Before and After Pouch Creation.Inflammatory bowel diseases · 2025Article
- Evaluation of the RIFER procedure in treating high intersphincteric anal fistulas.Frontiers in medicine · 2025Article
- Fistula in Crohn's disease: classification, pathogenesis, and treatment options.Tissue barriers · 2025Review
- Clinical and Radiological Features of Perianal Fistula: An MRI-Based Study in Addis Ababa, Ethiopia.Ethiopian journal of health sciences · 2024Article
- Achieving a high cure rate in complex anal fistulas: understanding the conceptual role of the Garg cardinal principles.Annals of coloproctology · 2024Article
- Development of a new patient-reported outcome measure for complex cryptoglandular fistulas (20-Item complex cryptoglandular fistula questionnaireJournal of patient-reported outcomes · 2024Article
- Efficacy and safety of transanal opening of intersphincteric space in the treatment of high complex anal fistula: A meta‑analysis.Experimental and therapeutic medicine · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptoglandular perianal fistula is a common benign anorectal disorder that is managed mainly with surgery. A fistula is typically defined as a pathological communication between two epithelialized surfaces. More specifically, perianal fistula manifests as an abnormal tract between the anorectal canal and the perianal skin. Perianal fistulas are often characterized by significantly decreased patient quality of life. The cryptoglandular theory of perianal fistulas suggests their development from the proctodeal glands, which originate from the intersphincteric plane and perforate the internal sphincter with their ducts. Involvement of proctodeal glands in the inflammatory process could play a primary role in the formation of cryptoglandular perianal fistula. The objective of this narrative review was to investigate the current knowledge of the pathogenesis of cryptoglandular perianal fistula with the specific aims of characterizing the potential role of proinflammatory factors responsible for the development of chronic inflammation. Further studies are crucial to improve the therapeutic management of cryptoglandular perianal fistulas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.