Evidence map›Paper›PMID 33595290›Full record

ArticleChemical research in toxicology2021

DNA Sequence Modulates the Efficiency of NEIL1-Catalyzed Excision of the Aflatoxin B

Rachana Tomar, Irina G Minko, Andrew H Kellum, Markus W Voehler, Michael P Stone, Amanda K McCullough, R Stephen Lloyd

Open access · greenAbstract read
In one paragraph

Article in Chemical research in toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. The aflatoxin BNAR cancer · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Frequencies and spectra of aflatoxin BNAR molecular medicine · 2024
    Article
  7. The aflatoxin BEnvironmental and molecular mutagenesis · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rachana TomarDepartment of Chemistry and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B, Box 351822, Nashville, Tennessee 37235, United States.
Irina G MinkoOregon Institute of Occupational Health Sciences, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States.
Andrew H KellumDepartment of Chemistry and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B, Box 351822, Nashville, Tennessee 37235, United States.
Markus W VoehlerDepartment of Chemistry and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B, Box 351822, Nashville, Tennessee 37235, United States.
Michael P StoneDepartment of Chemistry and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B, Box 351822, Nashville, Tennessee 37235, United States.ORCID 0000-0002-0922-0216
Amanda K McCulloughOregon Institute of Occupational Health Sciences, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States.
R Stephen LloydOregon Institute of Occupational Health Sciences, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States.ORCID 0000-0001-7273-372X
Vanderbilt University · USOregon Health & Science University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Synthetic Approaches to Carcinogen-Linked OligonucleotidesP01CA160032 · NCI · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 2012 to 2022
$14.0M
SYNTHETIC APPROACHES TO PAH-ADDUCTED NUCLEOTIDESP01ES005355 · NIEHS · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 1991 to 2010
$13.4M
DNA Adduct-Induced MutagenesisR01CA055678 · NCI · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 1992 to 2016
$4.0M
DNA Adduct-Induced MutagenesisR01ES029357 · NIEHS · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 2018 to 2022
$2.6M
Role of Base Excision Repair in Limiting Hepatocellular Carcinomas -Administrative SupplementR01ES031086 · NIEHS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LLOYD, R. STEPHEN · 2020 to 2024
$2.0M
Console upgrades for biological NMR spectrometersS10RR025677 · NCRR · VANDERBILT UNIVERSITY · PI SANDERS, CHARLES R · 2009 to 2009
$460k
NCI NIH HHS P01 CA160032NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA055678NCRR NIH HHS S10 RR025677NIEHS NIH HHS P01 ES005355NIEHS NIH HHS R01 ES029357NIEHS NIH HHS R01 ES031086
6 · The paper itself

Abstract

Dietary exposure to aflatoxins is a significant risk factor in the development of hepatocellular carcinomas. Following bioactivation by microsomal P450s, the reaction of aflatoxin B

Indexed as

Aflatoxin B1Base SequenceBiocatalysisDNADNA AdductsDNA GlycosylasesGuanineHumansMolecular StructurePyrimidines2,6-diamino-4-hydroxy-5-formamidopyrimidineAflatoxin B1DNADNA AdductsDNA GlycosylasesGuanineNEIL1 protein, humanPyrimidines

Identifiers

PMID33595290
PMCPMC8727046
OpenAlexW3131874567

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.