Evidence map›Paper›PMID 33595158›Full record

ReviewTransplant infectious disease : an official journal of the Transplantation Society2021

Cytomegalovirus antiviral stewardship in the COVID-19 Era: Increasing complexity of prophylaxis and treatment and potential mitigation strategies.

Margaret R Jorgenson, Jillian L Descourouez, Cynthia Wong, Jill R Strayer, Sandesh Parajuli, John P Rice, Robert R Redfield, Jeannina A Smith, Didier A Mandelbrot, Christopher M Saddler

Open access · bronzeAbstract readReview
In one paragraph

Review in Transplant infectious disease : an official journal of the Transplantation Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Impact of COVID-19 on Global Kidney Transplantation Service Delivery: Interim Report.Transplant international : official journal of the European Society for Organ Transplantation · 2022
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Margaret R JorgensonDepartment of Pharmacy, University of Wisconsin Hospital and Clinics, Madison, WI, USA.ORCID https://orcid.org/0000-0001-6088-9727
Jillian L DescourouezDepartment of Pharmacy, University of Wisconsin Hospital and Clinics, Madison, WI, USA.
Cynthia WongDepartment of Pharmacy, University of Wisconsin Hospital and Clinics, Madison, WI, USA.
Jill R StrayerDepartment of Pharmacy, University of Wisconsin Hospital and Clinics, Madison, WI, USA.
Sandesh ParajuliDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA.ORCID https://orcid.org/0000-0003-1667-7465
John P RiceDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA.
Robert R RedfieldDepartment of Surgery, University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA.
Jeannina A SmithDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA.
Didier A MandelbrotDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA.
Christopher M SaddlerDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA.ORCID https://orcid.org/0000-0002-6656-981X
University of Wisconsin–Madison · USUW Health University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytomegalovirus (CMV) infection is one of the most common and significant complications after solid organ transplant (SOT). Severe acute respiratory coronavirus 2 (SARS-CoV-2), which causes the novel betacoronavirus 2019 disease (COVID-19), has become the first global pandemic in 100 years. The world's attention has turned to address this unanticipated development; however, the viral infection that has long plagued outcomes after solid organ transplantation still requires vigilance. With physical distancing as the key intervention to reduce the healthcare burden, and the unease related to healthcare contact within the transplant population given the associated morbidity and mortality of COVID-19 in transplant recipients, providers have struggled to evaluate and streamline essential in-person healthcare contact, including laboratory visits. Owing to this, the COVID-19 pandemic has placed a significant strain on the delivery of CMV prophylaxis and treatment after solid organ transplantation. In this piece, we will describe issues our CMV antiviral stewardship service has encountered in the care of the transplant recipient with CMV during the this unprecedented time and share our expert opinion to approaches to providing optimal, evidenced based care during a pandemic associated with a seemingly unrelated viral infection.

Indexed as

COVID-19Organ TransplantationAntiviral AgentsCytomegalovirusHumansPandemicsSARS-CoV-2Antiviral Agentsinfection and infectious agentsquality of care/care deliveryviralviral: cytomegalovirus

Identifiers

PMID33595158
PMCPMC7995190
OpenAlexW3131722060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.