Evidence map›Paper›PMID 33595134›Full record

SynthesisJournal of medical virology2021

SARS-CoV-2 infection affects the lower urinary tract and male genital system: A systematic review.

Massimiliano Creta, Caterina Sagnelli, Giuseppe Celentano, Luigi Napolitano, Roberto La Rocca, Marco Capece, Gianluigi Califano, Armando Calogero, Antonello Sica, Francesco Mangiapia and 5 more

Open access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Longitudinal Evaluation of Lower Urinary Tract Symptoms up to Six Months after COVID-19 Infection in a Jordanian Cohort.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2025
    Article
  7. Article
  8. Article
  9. Prolonged urinary retention in COVID-19 survivors: observational study.Revista da Associacao Medica Brasileira (1992) · 2024
    Observational
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Issues related to post-COVID-19 syndrome.World journal of methodology · 2022
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Massimiliano CretaDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.
Caterina SagnelliDepartment of Mental health and Public Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID http://orcid.org/0000-0002-9943-9130
Giuseppe CelentanoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.
Luigi NapolitanoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.
Roberto La RoccaDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.
Marco CapeceDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.
Gianluigi CalifanoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.
Armando CalogeroDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Antonello SicaDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Francesco MangiapiaDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.
Massimo CiccozziMedical Statistics and Molecular Epidemiology Unit, Campus Bio-Medico University, Rome, Italy.ORCID http://orcid.org/0000-0003-3866-9239
Ferdinando FuscoDepartment of Woman, Child and General and Specialized Surgery, Urology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
Vincenzo MironeDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.
Evangelista SagnelliDepartment of Mental health and Public Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Nicola LongoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.
University of Naples Federico II · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversità Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed, Scopus, and ISI Web of Knowledge databases were searched to identify studies published up to December 2020 on the involvement of urinary and male genital systems in COVID-19. Sixteen studies involving a total of 575 patients (538 males and 37 females) were included in this systematic review. The COVID-19 phase was available for 479 patients: 426 in the acute and 53 in the recovery phase. De novo lower urinary tract symptoms (LUTS) were observed in 43 patients and deterioration of pre-existing LUTS in 7. Bladder hemorrhage was observed in three patients and acute urinary retention in one. Regarding the male genital system, scrotal discomfort was observed in 8 patients, swelling in 14, pain in 16, and erythema in 1; low flow priapism was observed in 2 patients. Ultrasound examination identified acute orchitis in 10 patients, acute epididymitis in 7, and acute epididymo-orchitis in 16. A case-control study reported that patients with moderate COVID-19 show a significant reduction in sperm concertation, the total number of sperms per ejaculate, progressive motility, and complete motility. In contrast to what is known from the first studies on the subject, this review also includes subsequent studies that give evidence of the involvement of the lower urinary tract and male genital system in COVID-19.

Indexed as

SARS-CoV-2COVID-19Genitalia, MaleHumansMaleUrinary TractcoronavirusCOVID-19disease controlgenital tractinfectionSARS-CoV-2urinary tract

Identifiers

PMID33595134
PMCPMC8013185
OpenAlexW3130226267

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.