Evidence map›Paper›PMID 33595089›Full record

ArticleSchizophrenia bulletin2021

Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective.

Hui Lin Ong, Adela-Maria Isvoranu, Frederike Schirmbeck, Philip McGuire, Lucia Valmaggia, Matthew J Kempton, Mark van der Gaag, Anita Riecher-Rössler, Rodrigo A Bressan, Neus Barrantes-Vidal and 14 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 16 institutions in 12 countries.

Hui Lin OngDepartment of Psychology, Psychological Methods, University of Amsterdam, Amsterdam, the Netherlands.
Adela-Maria IsvoranuDepartment of Psychology, Psychological Methods, University of Amsterdam, Amsterdam, the Netherlands.
Frederike SchirmbeckAmsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam, the Netherlands.
Philip McGuireDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.
Lucia ValmaggiaDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Matthew J KemptonDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.
Mark van der GaagAmsterdam Public Mental Health Research Institute, Department of Clinical Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Anita Riecher-RösslerMedizinische Fakultät, Universität Basel, Basel, Switzerland.
Rodrigo A BressanLiNC-Lab Interdisciplinar Neurociências Clínicas, Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Neus Barrantes-VidalDepartament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain.
Barnaby NelsonOrygen, Parkville, Victoria, Australia.
G Paul AmmingerOrygen, Parkville, Victoria, Australia.
Patrick McGorryOrygen, Parkville, Victoria, Australia.
Christos PantelisMelbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne & Melbourne Health, Carlton South, Victoria, Australia.ORCID 0000-0002-9565-0238
Marie-Odile KrebsUniversity of Paris, GHU-Paris, Sainte-Anne, C'JAAD, Inserm U1266, Institut de Psychiatrie (CNRS 3557), Paris, France.
Merete NordentoftMental Health Center Copenhagen and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Center Glostrup, Mental Health Services in the Capital Region of Copenhagen, University of Copenhagen, Copenhagen, Denmark.
Birte GlenthøjCentre for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.
Stephan RuhrmannDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Gabriele SachsDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Bart P F RuttenDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.
Jim van OsDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.
Lieuwe de HaanAmsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam, the Netherlands.
Denny BorsboomDepartment of Psychology, Psychological Methods, University of Amsterdam, Amsterdam, the Netherlands.
EU-GEI High Risk Study
King's College London · GBUniversity of Copenhagen · DKCentre National de la Recherche Scientifique · FRUniversity of Basel · CHUniversitat Autònoma de Barcelona · ESThe University of Melbourne · AUUniversidade Federal de São Paulo · BRUniversity of Cologne · DEMaastricht University Medical Centre · NLUniversity of Amsterdam · NLAmsterdam University Medical Centers · NLArkin · NLMedical University of Vienna · ATOrygen · AUInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz · MXVrije Universiteit Amsterdam · NL

Funding

Medical Research Council MR/J008915/1
6 · The paper itself

Abstract

backgroundThe high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis.

methodThree hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms.

resultsStrong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change.

conclusionsFindings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence.

Indexed as

AdultCase-Control StudiesFemaleHumansMaleObsessive-Compulsive DisorderPsychotic DisordersRisk AssessmentYoung Adultanxietyclinical high riskdepressionnetwork analysisobsessive-compulsivepsychosisultra-high risk

Identifiers

PMID33595089
PMCPMC8266672
OpenAlexW3132363857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.